Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7547
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dc.contributor.authorEdington, Fernando Luiz Barros
dc.contributor.authorBacellar, Maria Olívia Amado Ramos
dc.contributor.authorMachado, Paulo Roberto
dc.contributor.authorBarbosa, Lúcio Macedo
dc.contributor.authorReis, Eliana Almeida Gomes
dc.contributor.authorReis, Mitermayer Galvão dos
dc.contributor.authorSantiago, Mittermayer Barreto
dc.date.accessioned2014-04-28T13:00:13Z
dc.date.available2014-04-28T13:00:13Z
dc.date.issued2007
dc.identifier.citationEDINGTON, F. L. B. et al. Anti-neutrophil cytoplasmic antibodies in leprosy. Clinical Rheumatology, v. 26, n. 2, p. 208-210, 2007.
dc.identifier.issn0770-3198
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7547
dc.language.isoeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.titleAnti-neutrophil cytoplasmic antibodies in leprosy.
dc.typeArticle
dc.identifier.doi10.1007/s10067-006-0281-7
dc.description.abstractenIntroduction: Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are auto-antibodies directed to intracellular components of neutrophils and used to be considered as present almost exclusively in granulomatous vasculitis. Recently, these auto-antibodies have been found in other autoimmune disorders as well as infectious diseases. Materials and methods: We studied patients with leprosy confirmed by bacilloscopy and/or skin biopsy, in reaction phase from the Ambulatório de Hanseníase do Hospital Universitário Professor Edgar Santos. ANCA and Antinuclear antibodies (ANA) were determined by indirect immunofluorescence using commercially available kits. Results: Twenty patients were enrolled in our study, nine males and 11 females. The mean age was 36.9± 18.2 years. ANCA were present only in one patient, with a perinuclear staining pattern (p-ANCA), and no patient tested positive for ANA. Discussion: Although other studies have shown the presence of ANCA in leprosy, the low frequency of these antibodies in leprosy sera demonstrated in the present study illustrates the high specificity of ANCA for the diagnosis of Wegener granulomatosis.
dc.creator.affilliationUniversidade Federal da Bahia. Salvador, BA, Brasil /
dc.creator.affilliationUniversidade Federal da Bahia. Laboratório de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil
dc.creator.affilliationEscola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia, Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
dc.creator.affilliationEscola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Serviço de Reumatologia. Salvador, BA, Brasil
dc.subject.enAuto-antibodies
dc.subject.enHansen disease
dc.subject.enLeprosy
dc.subject.enVasculitis
dc.subject.decsAnticorpos Anticitoplasma de Neutrófilos/sangue
dc.subject.decsHanseníase/imunologia
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsIdoso
dc.subject.decsBiópsia
dc.subject.decsCriança
dc.subject.decsFeminino
dc.subject.decsTécnica Indireta de Fluorescência para Anticorpo
dc.subject.decsHumanos
dc.subject.decsHanseníase/patologia
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsMycobacterium leprae/citologia
dc.subject.decsMycobacterium leprae/isolamento & purificação
dc.subject.decsKit de Reagentes para Diagnóstico
dc.subject.decsPele/microbiologia
dc.subject.decsPele/patologia
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