Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7559
Title: Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?
Authors: Paraná, Raymundo
Codes, Liana
Andrade, Zilton de Araújo
Freitas, Luiz Antonio Rodrigues de
Jesus, Rogério Santos
Reis, Mitermayer Galvão dos
Cotrim, Helma Pinchemel
Cunha, Simone
Trépo, Christian
Affilliation: University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil
University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil
University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil
Inserm U. Lyon, France
Abstract: Non-A-E hepatitis and acute cryptogenic hepatitis are the names given to the disease of patients with clinical hepatitis, but in whom serologic evidence of A-E hepatitis has not been found. Over a period of 8 years, we evaluated in Brazil 32 patients who fulfilled the criteria for this diagnosis in order to determine patterns of the clinical illness, laboratory parameters, or histologic features. Each patient was subjected to virologic tests to exclude A-E hepatitis and cytomegalovirus/Epstein-Barr virus infection. Drug-induced hepatitis and autoimmune disease were also excluded. Wilson's disease was excluded in young patients. The course of the disease was clinical/biochemical recovery in 3 months in 25 patients and persistent alanine aminotransferase (ALT) elevation in 7 patients. Three of these had chronic hepatitis, and one had severe fibrosis on liver biopsy. During the acute illness, mean peak ALT was 1267 IU/L, bilirubin was 4.0 mg/dL, and ferritin was 1393 IU/mL. GB virus type C (GBV-C) was found in six patients, and TT virus (TTV) in five patients. We conclude that, in Brazil, non-A-E hepatitis probably originates from still unidentified viruses. The course of the disease and the histologic patterns are similar to those recorded for known viruses. Continuous survey for the specific etiologic agents is needed.
DeCS: Vírus GB C/isolamento & purificação
Hepatite Viral Humana/fisiopatologia
Hepatite Viral Humana/virologia
Torque teno virus/isolamento & purificação
Doença Aguda
Adolescente
Adulto
Alanina Transaminase/sangue
Anticorpos Antivirais/sangue
Brasil
Criança
Estudos de Coortes
Doenças Transmissíveis/virologia
Feminino
Hepatite Viral Humana/imunologia
Humanos
Fígado/patologia
Masculino
Meia-Idade
Issue Date: 2003
Publisher: International Society for Infectious Diseases
Citation: PARANÁ, R. et al. Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? International Journal of Infectious Disease, v. 7, n. 3, p. 222-230, 2003.
ISSN: 1201-9712
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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