Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7562
Title: Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease.
Authors: Blanton, Ronald Edward
Salam, Ekram Abdel
Kariuki, H. Curtis
Magak, Philip
Silva, Luciano Kalabric
Muchiri, Eric M.
Thiongo, Fredrick
Meghid, Iman E.Abdel
Butterworth, Anthony E
Reis, Mitermayer Galvão dos
Ouma, John H.
Affilliation: Division of Geographic Medicine. Case Western Reserve University. Cleveland, Ohio
University of Cairo. Department of Pediatrics. Cairo, Egypt
Division of Vector Borne Diseases. Nairobi
Office of Radiologic Services. Kenya Ministry of Health. Nairobi, Kenya
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Division of Vector Borne Diseases. Nairobi
Division of Vector Borne Diseases. Nairobi
University of Cairo. Department of Pediatrics. Cairo, Egypt
Biomedical Research and Training Institute. Harare, Zimbabwe
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Division of Vector Borne Diseases. Nairobi
Abstract: Two populations with differing histories of Schistosoma mansoni and hepatitis C infection were compared directly for severity of disease and extent of comorbidity. Demographic, parasitologic, and ultrasound surveys were conducted on 2038 Egyptians and on 2120 Kenyans. Hepatitis B and C serologies and transaminase levels were obtained from a subset at each site. Despite significantly lower prevalence and intensity of infection, Egyptians had a higher prevalence of severe schistosomal fibrosis than Kenyans (36.8% vs. 4.6%). Hepatitis C infection was 3 times more prevalent among Egyptians, and evidence of hepatocellular damage was significantly greater among Egyptians. There was no interaction between S. mansoni infection or disease and the prevalence or severity of hepatitis C. For both infections, the intensity or prevalence of infection was a poor predictor of morbidity. The prevalence of disease in the Egyptian population from different pathogens suggests a generalized susceptibility to inflammatory liver disease.
DeCS: Hepatite C/epidemiologia
Vigilância da População
Esquistossomose mansoni/epidemiologia
Índice de Gravidade de Doença
Adolescente
Adulto
Animais
Criança
Comorbidade
Egito/epidemiologia
Feminino
Hepacivirus/patogenicidade
Hepatite C/ultrassonografia
Humanos
Quênia/epidemiologia
Fígado/ultrassonografia
Masculino
Schistosoma mansoni/patogenicidade
Meia-Idade
Esquistossomose mansoni/ultrassonografia
Issue Date: 2002
Publisher: Infectious Diseases Society of America
Citation: BLANTON R. E. et al. Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. Journal of Infectious Disease, v. 185, n. 11, p. 1644-1649, 2002.
ISSN: 0022-1899
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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