Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7575
Title: Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil
Authors: Oliveira, Ana Marlucia de
Barreto, Maurício Lima
Prado, Matildes da Silva
Reis, Mitermayer Galvão dos
Parraga, Isabel Martin
Blanton, Ronald Edward
Affilliation: Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Abstract: Brazilian schoolchildren with mild- to moderate-intensity schistosome infections (<400 Schistosoma mansoni eggs/g stool) were randomly allocated to a treatment (oxamniquine) or placebo group in a double-blind fashion. Anthropometric measurements were made at baseline, 6 mo, and 1 y for 353 students. At baseline, the groups were not significantly different with respect to nutritional status or selected socioeconomic and biological characteristics, including anthropometric measures. One year later, significant differences were noted only in the nutritional status of boys treated for schistosome infection. Treated boys had greater measurements for weight, triceps skinfold thickness, midarm circumference, arm muscle area, and body mass index than untreated boys. They also showed significant increases over the year in weight, height, midarm circumference, and body mass index. The rates of improvement in weight and height were more accelerated in the first 6 mo after therapy than the last. These results indicate that, at least in boys, chronic S. mansoni infection at any intensity is detrimental to short-term growth and development.
Keywords: Schistosoma mansoni
Growth
Sex
Oxamniquine
Morbidity
Therapy
Anthropometry
Parasitic infection
Schoolchildren
DeCS: Estado Nutricional
Oxamniquine/uso terapêutico
Esquistossomose mansoni/quimioterapia
Esquistossomicidas/uso terapêutico
Adolescente
Antropometria
Índice de Massa Corporal
Peso Corporal
Brasil
Criança
Método Duplo-Cego
Feminino
Humanos
Masculino
Placebos
Esquistossomose mansoni/fisiopatologia
Pregas Cutâneas
Issue Date: 1998
Publisher: American Society for Clinical Nutrition
Citation: ASSIS, A. M. O. et al. Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil. American Journal of Clinical Nutrition, v. 68, n. 6, p. 1247-1253, 1998.
ISSN: 0002-9165
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

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