Author | Secor, William E | |
Author | Del Corral, Helena | |
Author | Reis, Mitermayer Galvão dos | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Zimon, Alison E | |
Author | Matos, E. Peixoto | |
Author | Reis, Eliana Almeida Gomes | |
Author | Carmo, Theomira Mauadie de Azevedo | |
Author | Hirayama, Kenji | |
Author | David, Roberta A | |
Author | David, John R | |
Author | Harn Junior, Donald A | |
Access date | 2014-05-05T13:28:56Z | |
Available date | 2014-05-05T13:28:56Z | |
Document date | 1996 | |
Citation | SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996. | pt_BR |
ISSN | 0022-1899 | |
URI | https://www.arca.fiocruz.br/handle/icict/7576 | |
Language | eng | pt_BR |
Publisher | The University of Chicago Press | pt_BR |
Rights | open access | pt_BR |
Title | Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 | pt_BR |
Type | Article | pt_BR |
Abstract | Major histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma
mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency
analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response
to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic
disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for
DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall
study population. However, using stringent Bonferroni correction (multiplying P values by the
number of alleles tested; P X 35), none of these associations with SEA responsiveness remained
significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more
likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association
remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction. | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Department of Medical Zoology. Saitama Medical School. Saitama, Japan | pt_BR |
Affilliation | Department of Medical Zoology. Saitama Medical School. Saitama, Japan | pt_BR |
Affilliation | Department of Medical Zoology. Saitama Medical School. Saitama, Japan | pt_BR |
Affilliation | Department of Medical Zoology. Saitama Medical School. Saitama, Japan | pt_BR |
DeCS | Antígenos HLA-DQ/genética | pt_BR |
DeCS | Hepatopatias Parasitárias/imunologia | pt_BR |
DeCS | Esquistossomose mansoni/imunologia | pt_BR |
DeCS | Esplenopatias/imunologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Alelos | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Cadeias beta de HLA-DQ | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |