Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7583
Title: Estudo sorbre o papel dos eosinófilos na destruicão dos esquistossômulos do Schistosoma mansoni in vivo
Authors: Andrade, Zilton de Araújo
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Schistosoma mansoni cercariae mechanically transformed into schistosomula were injected, either dead or alive, into the tail vein (2.000 larvae/0,15 ml) of Balb/c mice which were either previously infected with S. mansoni (10 weeks/50 cercariae) or non-infected. Histological examination of the lungs 24, 48, 72 and 96 hours after injection revealed that inflammatory reaction around schistosomula occurred only in the groups injected with dead schistosomula (killed by freezing and thawing). In non-infected animals the reaction was predominantly macrophagic while in those infected many eosinophils appeared around the dead larvae. These results are at variance with those obtained in vitro and suggest that in vivo the participation of eosinophils in the schistosomulum induced reaction in sensitized animals is secondary to the death of the larvae
DeCS: Anticorpos/imunologia
Eosinófilos/fisiologia
Schistosoma mansoni/imunologia
Animais
Formação de Anticorpos
Interações Hospedeiro-Parasita
Pulmão/patologia
Camundongos
Camundongos Endogâmicos BALB C
Esquistossomose/imunologia
Esquistossomose/patologia
Issue Date: 1984
Publisher: Fiocruz
Citation: ANDRADE, Z. A.; REIS, M. G. dos Estudo sorbre o papel dos eosinófilos na destruicão dos esquistossômulos do Schistosoma mansoni in vivo. Memórias do Instituto Oswaldo Cruz, v. 79, n. 3, p. 371-373, 1984.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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