Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7612
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dc.contributor.authorAlmeida, Roque Pacheco de
dc.contributor.authorBarral Netto, Manoel
dc.contributor.authorJesus, Amélia Maria Ribeiro de
dc.contributor.authorFreitas, Luiz Antonio Rodrigues de
dc.contributor.authorCarvalho Filho, Edgar Marcelino
dc.contributor.authorBarral, Aldina Maria Prado
dc.date.accessioned2014-05-13T13:56:28Z
dc.date.available2014-05-13T13:56:28Z
dc.date.issued1996
dc.identifier.citationALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.
dc.identifier.issn0002-9637
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7612
dc.language.isoeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.titleBiological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
dc.typeArticle
dc.description.abstractenLeishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to the altered course of the disease in humans and in isogenic BALB/c mice.
dc.creator.affilliationHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
dc.subject.decsLeishmania/patogenicidade
dc.subject.decsLeishmaniose Cutânea/parasitologia
dc.subject.decsLeishmaniose Mucocutânea/parasitologia
dc.subject.decsLeishmaniose Visceral/parasitologia
dc.subject.decsAnimais
dc.subject.decsAnticorpos Antiprotozoários/sangue
dc.subject.decsFeminino
dc.subject.decsHumanos
dc.subject.decsImunoglobulina G/sangue
dc.subject.decsLeishmania/imunologia
dc.subject.decsMasculino
dc.subject.decsCamundongos
dc.subject.decsCamundongos Endogâmicos BALB C
Appears in Collections:BA - IGM - Artigos de Periódicos

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