| Author | Almeida, Roque Pacheco de | |
| Author | Barral Netto, Manoel | |
| Author | Jesus, Amélia Maria Ribeiro de | |
| Author | Freitas, Luiz Antonio Rodrigues de | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Author | Barral, Aldina Maria Prado | |
| Access date | 2014-05-13T13:56:28Z | |
| Available date | 2014-05-13T13:56:28Z | |
| Document date | 1996 | |
| Citation | ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996. | pt_BR |
| ISSN | 0002-9637 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7612 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | pt_BR |
| Title | Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice | pt_BR |
| Type | Article | pt_BR |
| Abstract | Leishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated
BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or
visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with
parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the
spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated
from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell
infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination
of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings
demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients
with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to
the altered course of the disease in humans and in isogenic BALB/c mice. | pt_BR |
| Affilliation | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| DeCS | Leishmania/patogenicidade | pt_BR |
| DeCS | Leishmaniose Cutânea/parasitologia | pt_BR |
| DeCS | Leishmaniose Mucocutânea/parasitologia | pt_BR |
| DeCS | Leishmaniose Visceral/parasitologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anticorpos Antiprotozoários/sangue | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imunoglobulina G/sangue | pt_BR |
| DeCS | Leishmania/imunologia | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Camundongos Endogâmicos BALB C | pt_BR |
