Author | Maia Junior, Hugo | |
Author | Pimentel, Kleber | |
Author | Silva, Tânia Maria Correia | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Zausner, Bela | |
Author | Athayde, Célia | |
Author | Coutinho, Elsimar Metzker | |
Access date | 2014-06-27T17:10:07Z | |
Available date | 2014-06-27T17:10:07Z | |
Document date | 2006 | |
Citation | MAIA JUNIOR, R. et al. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle.Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Gynecological Endocrinology, v. 22, n. 4, p. 219–224, 2006. | pt_BR |
ISSN | 0951-3590 | |
URI | https://www.arca.fiocruz.br/handle/icict/7849 | |
Language | eng | pt_BR |
Publisher | Taylor & Francis | pt_BR |
Rights | open access | pt_BR |
Title | Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1080/09513590600585955 | |
Abstract | Objectives. To study the changes in aromatase, Ki-67 and cyclooxygenase-2 (COX-2) expression during the menstrual cycle
in both endometrial polyps and normal endometria.
Patients and methods. Paraffin-embedded tissue samples from 118 premenopausal patients were submitted to
immunohistochemistry for measurement of aromatase, COX-2 and Ki-67 expression. Fifty cases of endometrial polyps
and 68 cases of disease-free endometrium were included.
Results. The presence of aromatase expression was significantly higher in endometrial polyps than in disease-free
endometria. On the other hand, changes in COX-2 and Ki-67 expression followed a similar pattern during the menstrual
cycle in both groups, expression peaking during the proliferative phase and falling during the late luteal phase.
Conclusion. A significantly higher proportion of endometrial polyps express aromatase compared with disease-free
endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2
expression during the menstrual cycle. | pt_BR |
Affilliation | Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina. Salvador, Ba, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina. Salvador, Ba, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Genesis IVF Clinic. Salvador, BA, Brasil | pt_BR |
Affilliation | Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, Brasil | pt_BR |
Affilliation | Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, Brasil | pt_BR |
Subject | Aromatase expression | pt_BR |
Subject | Endometrial polyps | pt_BR |
Subject | Ki-67 | pt_BR |
Subject | Cyclooxygenase-2 | pt_BR |
DeCS | Aromatase/metabolismo | pt_BR |
DeCS | Ciclo-Oxigenase 2/metabolismo | pt_BR |
DeCS | Endométrio/metabolismo | pt_BR |
DeCS | Antígeno Ki-67/metabolismo | pt_BR |
DeCS | Pólipos/metabolismo | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Distribuição de Qui-Quadrado | pt_BR |
DeCS | Endométrio/patologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Ciclo Menstrual/fisiologia | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Estudos Retrospectivos | pt_BR |
DeCS | Estatísticas não Paramétricas | pt_BR |