Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7885
Title: American cutaneous leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-methilglucamine antimoniate plus pentoxifylline.
Authors: Bafica, Andre Luiz Barbosa
Oliveira, Fabiano
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane Góes
Barral, Aldina Maria Prado
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Centro Referência em Doenças Endêmicas Pirajá da Silva. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Background American cutaneous leishmaniasis is characterized by single or multiple ulcerations. Cytokines, among other factors, have been shown to influence lesion development and tumoral necrosis factor-alpha is a major cytokine implicated in pathogenesis of ulcers. Observations We tested oral pentoxifylline, a known tumoral necrosis factor-alpha inhibitor, at doses of 400 mg (2–3x/day), associated to N-methylglucamine antimoniate (15 mg/kg/day) in two patients with American cutaneous leishmaniasis unresponsive to antimonial drugs. We observed a satisfactory response with quick cure of skin lesions of these patients. Conclusions Our results suggest that oral pentoxifylline in association to N-methylglucamine antimoniate should be consider in refractory cutaneous leishmaniasis patients
DeCS: Antiprotozoários/administração & dosagem
Leishmaniose Cutânea/quimioterapia
Meglumina/administração & dosagem
Compostos Organometálicos/administração & dosagem
Pentoxifilina/administração & dosagem
Quimioterapia Combinada
Feminino
Humanos
Leishmaniose Cutânea/metabolismo
Leishmaniose Cutânea/patologia
Masculino
Meia-Idade
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Fator de Necrose Tumoral alfa/metabolismo
Issue Date: 2003
Publisher: The International Society of Dermatology
Citation: BÁFICA, A. L. B. et al. American cutaneous leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-methilglucamine antimoniate plus pentoxifylline. International Journal of Dermatology, v. 42, n. 3, p. 203-207, 2003.
ISSN: 0011-9059
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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