Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7942
Title: The association of infection and clinical severity in sickle cell anaemia patients.
Authors: Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, Brasil
Fundacao de Hematologia e Hemoterapia do Estado da Bahia (HEMOBA). Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, Brasil
Abstract: Sickle cell anaemia (SCA) patients have a high risk of infection. We retrospectively investigated the prevalence of infection among SCA patients from Bahia, Brazil. A total of 1415 SCA patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis C virus (HCV), 67 (4.7%) had human T-lymphotropic virus type I (HTLV-I), 44 (3.1%) had hepatitis B virus (HBV), 40 (2.8%) had Chagas’ disease, 11 (0.8%) had human immunodeficiency virus (HIV), and 5 (0.4%) had syphilis. Patients with HCV infection had a higher risk of hospitalisation (OR = 1.52, 95% Cl: 1.07-2.17, P = 0.020), bone disorders (OR = 1.94, 95% Cl: 1.15-3.27, P = 0.011), stroke (OR = 2.17, 95% Cl: 1.12–4.14, P = 0.017), painful crisis (OR = 1.61, 95% Cl: 1.17-2.22, P = 0.004) and leg ulcers (OR = 1.61, 95% Cl: 1.04-3.03, P = 0.031). Patients with HBV infection had a higher risk for bone disorders (OR = 4.90, 95% Cl: 2.08-11.54, P < .010), stroke (OR = 3.01, 95% Cl: 1.29-6.04, P = 0.007), painful crisis (OR = 3.51, 95% Cl: 1.62-7.63, P < 0.001), acute chest syndrome (ACS) (OR = 2.66, 95% Cl: 1.34-5.28, P = 0.004), leg ulcers (OR = 6.60, 95% Cl: 3.37-12.91, P < .001) and vaso-occlusive crisis (OR = 6.34, 95% Cl: 1.96- 20.66, P < 0.001). Patients with HTLV-I infection had a high risk for bone disorders (OR = 2.94, 95% Cl: 1.28-6.74, P = 0.011), respiratory failure (OR = 2.66, 95% Cl: 1.26-5.51, P = 0.012), leg ulcers (OR = 3.27, 95% Cl: 1.69-6.11, P < .001), painful crisis (OR = 1.82, 95% Cl: 1.07-3.13, P = 0.025) and ACS (OR = 1.85, 95% Cl: 1.10-3.41, P < .047). SCA patients with HCV infection had increased triglycerides and low-density lipoprotein cholesterol (P = 0.036; P = 0.027), iron serum (P = 0.016) and ferritin (P = 0.007). These results reveal important roles for these infections in SCA patients’ clinical outcomes, and studies are warranted to determine the mechanisms utilised by these agents and their involvement in disease severity.
Keywords: Sickle cell anaemia
Infection
Human T-lymphotropic virus
Hepatitis
keywords: Anemia falciforme
Virus T-limfotropico humano
Hepatite
Infecção
DeCS: Anemia Falciforme/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Sífilis/epidemiologia
Anemia Falciforme/complicações
Transfusão de Sangue/efeitos adversos
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Estudos Retrospectivos
Fatores de Risco
Índice de Gravidade de Doença
Adulto Jovem
Issue Date: 2011
Publisher: Elsevier
Citation: MOURA NETO, J. P. et al. The association of infection and clinical severity in sickle cell anaemia patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 3, p. 121-126, 2011.
DOI: 10.1016/j.trstmh.2010.11.007
ISSN: 1878-3503
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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