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LEUKOTRIENES ARE UPREGULATED AND ASSOCIATED WITH HUMAN T-LYMPHOTROPIC VIRUS TYPE 1 (HTLV-1)-ASSOCIATED NEUROINFLAMMATORY DISEASE
10.1371/journal.pone.0051873
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Afiliação
Resumo em Inglês
Leukotrienes (LTs) are lipid mediators involved in several inflammatory disorders. We investigated the LT pathway in human T-lymphotropic virus type 1 (HTLV-1) infection by evaluating LT levels in HTLV-1-infected patients classified according to the clinical status as asymptomatic carriers (HACs) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Bioactive LTB4 and CysLTs were both increased in the plasma and in the supernatant of peripheral blood mononuclear cell cultures of HTLV-1-infected when compared to non-infected. Interestingly, CysLT concentrations were increased in HAM/TSP patients. Also, the concentration of plasma LTB4 and LTC4 positively correlated with the HTLV-1 proviral load in HTLV-1-infected individuals. The gene expression levels of LT receptors were differentially modulated in CD4+ and CD8+ T cells of HTLV-1-infected patients. Analysis of the overall plasma signature of immune mediators demonstrated that LT and chemokine amounts were elevated during HTLV-1 infection. Importantly, in addition to CysLTs, IP-10 was also identified as a biomarker for HAM/TSP activity. These data suggest that LTs are likely to be associated with HTLV-1 infection and HAM/TSP development, suggesting their putative use for clinical monitoring.
Editor
Public Library of Science
Referência
TRINDADE, Bruno Caetano et al. Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease. Plos One. 2012, vol.7, pp. e51873ISSN
1932-620310.1371/journal.pone.0051873
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