Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8054
Title: HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence.
Authors: Mello, Marco Antônio Gomes
Conceição, Aline Ferreira da
Sousa, Sandra Mara Bispo
Alcantara, Luiz Carlos Júnior
Marin, Lauro Juliano
Raio, Mônica Regina da Silva
Boa-Sorte, Ney Cristian Amaral
Santos, Lucas Pereira de Souza
Almeida, Maria da Conceição Chagas de
Galvão, Tâmara Coutinho
Bastos, Raquel Gois
Lázaro, Noilson
Castro Filho, Bernardo Galvão
Gadelha, Sandra Rocha
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Faculdade de Ilhéus. Ilhéus, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Universidade Estadual do Sudoeste da Bahia. Vitória da Conquista, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Epidemiologia Molecular e Bioestatística. Salvador, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil
Abstract: BACKGROUND: As the most frequent pathway of vertical transmission of HTLV-1 is breast-feeding, and considering the higher prevalence in women, it is very important to perform screening examinations for anti-HTLV-1 antibodies as part of routine prenatal care. So far, no studies of HTLV-1 seroprevalence in pregnant women in the Southern region of Bahia, Brazil, have been described. METHODS: Pregnant women were selected at the two regional reference centers for health care from Southern Bahia. A total of 2766 pregnant women attending the antenatal unit between November 2008 and May 2010 have been analyzed. An extra blood sample was drawn during their routine antenatal testing. A standardized questionnaire was applied and all positive plasma samples were tested by ELISA and were confirmed by Western Blot and PCR. Besides that, positive women were contacted and visited. The family members that were present during the visit were asked to be serologically screened to the virus. A prospective study was also carried out and newborns were followed up to two years for evaluation of vertical transmission. RESULTS: HTLV prevalence was 1.05% (CI 95%: 0.70-1.50). There was no association of HTLV-1 infection with age, education, income and ethnic differences. The association with marital status was borderline (OR = 7.99; 95% CI 1.07-59.3; p = 0.042). In addition, 43 family members of the HTLV-1 seropositive women have been analyzed and specific reactivity was observed in 32.56%, including two children from previous pregnancy.Conclusion: It is very important to emphasize that the lack of HTLV-1 screening in pregnant women can promote HTLV transmission especially in endemic areas. HTLV screening in this vulnerable population and the promotion of bottle-feeding for children of seropositive mothers could be important cost-effective methods to limit the vertical transmission. Besides that, our data reinforce the need to establish strategies of active surveillance in household and family contacts as important epidemiological surveillance actions for the early detection of virus infection and the prevention of transmission by sexual or and parenteral contact.
Keywords: HTLV
Bahia-Brazil
Vertical transmission
Pregnant
Prenatal care
Issue Date: 2014
Publisher: BioMed Central
Citation: MELLO, M. A. G. et al. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. Virology Journal, v. 11, p. 28, 2014.
DOI: 10.1186/1743-422X-11-28
ISSN: 1743-422X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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