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https://www.arca.fiocruz.br/handle/icict/8130
HLA CLASS II ALLELES AND CHRONIC HEPATITIS C VIRUS INFECTION
Hepatitis C, Chronic/genetics
Hepatitis C, Chronic/pathology
HLA-DRB1*11 antigen
Author
Affilliation
Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil
Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil
Abstract
The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis/cirrhosis (METAVIR scores F3-F4) was present in 49 patients. HLA-DRB1 specificities and DRB1*11 and DQB1* alleles were determined by PCR-SSP, and their frequencies were compared between patients and a control group of 103 healthy white Brazilian individuals. The results confirmed previous reports of the association of DRB1*11 and DQB1*03 with protection from chronic HCV infection, but did not confirm their association with protection from severe fibrosis/cirrhosis. Furthermore, the results suggested that the polymorphic sites on HLA molecules responsible for protection from chronic HCV infection are encoded not only by the DRB1*1101 and DQB1*0301, as suggested in the literature, but also by other DRB1*11 and DQB1*03 alleles. Thus, we hypothesized that the common polymorphic residues shared by different DRB1*11 and/or DQB1*03 alleles might be responsible for selection of viral epitopes for presentation to CD4(+) T cells, leading to an efficient immune response against the virus.
Keywords in Portuguese
LimaKeywords
CD4-Positive T-LymphocytesHepatitis C, Chronic/genetics
Hepatitis C, Chronic/pathology
HLA-DRB1*11 antigen
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