Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8296
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dc.contributor.authorLima, Ana Tereza Cerqueira
dc.contributor.authorNeves, Neuza Maria Alcântara
dc.contributor.authorPontes-de-Carvalho, Lain Carlos
dc.contributor.authorCosta, Ryan dos Santos
dc.contributor.authorBarbosa Filho, José Maria
dc.contributor.authorPiuvezam, Márcia
dc.contributor.authorRusso, Momtchilo
dc.contributor.authorBarboza, Renato
dc.contributor.authorOliveira, Eduardo de Jesus
dc.contributor.authorMarinho, Alexsandro
dc.contributor.authorFigueiredo, Camila Alexandrina Viana
dc.date.accessioned2014-08-29T18:43:05Z
dc.date.available2014-08-29T18:43:05Z
dc.date.issued2010
dc.identifier.citationCERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010.
dc.identifier.issn1873-5592
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/8296
dc.language.isoeng
dc.publisherBentham Science Publishers Ltd.
dc.rightsopen access
dc.titleEffects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
dc.typeArticle
dc.description.abstractenAsthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatment
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
dc.creator.affilliationUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
dc.creator.affilliationUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil
dc.creator.affilliationUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil
dc.creator.affilliationUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
dc.creator.affilliationUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
dc.subject.enAsthma
dc.subject.enBlomia tropicalis
dc.subject.enCissampelos sympodialis
dc.subject.enNatural products
dc.subject.enWarifteine
dc.subject.enCytokines
dc.subject.decsAlcaloides/farmacologia
dc.subject.decsAsma/quimioterapia
dc.subject.decsAsma/imunologia
dc.subject.decsCissampelos/química
dc.subject.decsÁcaros/imunologia
dc.subject.decsAlcaloides/isolamento & purificação
dc.subject.decsAnimais
dc.subject.decsAsma/metabolismo
dc.subject.decsLíquido da Lavagem Broncoalveolar/citologia
dc.subject.decsCitocinas/imunologia
dc.subject.decsCitocinas/metabolismo
dc.subject.decsPeroxidase de Eosinófilo/metabolismo
dc.subject.decsFeminino
dc.subject.decsImunoglobulina E/imunologia
dc.subject.decsCamundongos
dc.subject.decsCamundongos Endogâmicos A
dc.subject.decsModelos Teóricos
dc.subject.decsExtratos Vegetais/farmacologia
dc.subject.decsFolhas de Planta/química
dc.subject.decsRatos
dc.subject.decsRatos wistar
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