| Author | Inam, Afreen | |
| Author | Siddiqui, Shadab Miyan | |
| Author | Macedo, Taís Soares | |
| Author | Moreira, Diogo Rodrigo Magalhães | |
| Author | Leite, Ana Cristina Lima | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Azam, Amir | |
| Access date | 2014-09-26T16:57:39Z | |
| Available date | 2014-09-26T16:57:39Z | |
| Document date | 2014 | |
| Citation | INAM, A. et al. Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. European Journal of Medicinal Chemistry, v. 75, p. 67-76, 2014. | pt_BR |
| ISSN | 1768-3254 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8459 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Masson SAS | pt_BR |
| Rights | open access | pt_BR |
| Title | Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.ejmech.2014.01.023 | |
| Abstract | N-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and biologically
evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica trophozoites. N-Acylhydrazone
F12 was found to inhibit the P. falciparum growth as well as its life cycle with good selectivity,
which was achieved by inhibiting hematin formation. Compound F24 showed better IC50 value than the
amoebicidal drug metronidazole | pt_BR |
| Affilliation | Jamia Millia Islamia. Department of Chemistry. Jamia Millia Islamia, Jamia Nagar. New Delhi, India | pt_BR |
| Affilliation | Jamia Millia Islamia. Department of Chemistry. Jamia Millia Islamia, Jamia Nagar. New Delhi, India | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Jamia Millia Islamia. Department of Chemistry. Jamia Millia Islamia, Jamia Nagar. New Delhi, India | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Amoebiasis | pt_BR |
| Subject | Aminoquinoline | pt_BR |
| Subject | Piperazinyl derivatives | pt_BR |
| Subject | Acylhydrazone | pt_BR |
