Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8462
Title: Antiparasitic activities of novel ruthenium/lapachol complexes.
Authors: Barbosa, Marília Imaculada Frazão
Corrêa, Rodrigo de Souza
Oliveira, Katia Mara de
Rodrigues, Claudia
Ellena, Javier Alcides
Nascimento, Otaciro Rangel
Rocha, Vinícius Pinto Costa
Nonato, Fabiana Regina
Macedo, Taís Soares
Barbosa Filho, José Maria
Soares, Milena Botelho Pereira
Batista, Alzir Azevedo
Affilliation: Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil
Abstract: The present study describes the synthesis, characterization, antileishmanial and antiplasmodial activities of novel diimine/(2,2'-bipyridine (bipy), 1,10-phenanthroline (phen), 4,4'-methylbipyridine (Me-bipy) and 4,4'-methoxybipyridine (MeO-bipy)/phosphine/ruthenium(II) complexes containing lapachol (Lap, 2-hydroxy-3-(3-33 methyl-2-buthenyl)-1,4-naphthoquinone) as bidentate ligand. The [Ru(Lap)(PPh3)2(bipy)]PF6 (1), [Ru(Lap)(PPh3)2(Me-bipy)]PF6 (2), [Ru(Lap)(PPh3)2(MeO-bipy)]PF6(3) and[Ru(Lap)(PPh3)2(phen)]PF6 (4) complexes, PPh3=triphenylphospine, were synthesized from the reactions of cis-[RuCl2(PPh3)2(X-bipy)] or cis-[RuCl2(PPh3)2(phen)], with lapachol. The [RuCl2(Lap)(dppb)] (5) [dppb=1,4-bis(diphenylphosphine)butane] was synthesized from the mer-[RuCl3(dppb)(H2O)] complex. The complexes were characterized by elemental analysis, molar conductivity, infrared and UV-vis spectroscopy, (31)P{(1)H} and (1)H NMR, and cyclic voltammetry. The Ru(III) complex, [RuCl2(Lap)(dppb)], was also characterized by the EPR technique. The structure of the complexes [Ru(Lap)(PPh3)2(bipy)]PF6 and [RuCl2(Lap)(dppb)] was elucidated by X-ray diffraction. The evaluation of the antiparasitic activities of the complexes against Leishmania amazonensis and Plasmodium falciparum demonstrated that lapachol-ruthenium complexes are more potent than the free lapachol. The [RuCl2(Lap)(dppb)] complex is the most potent and selective antiparasitic compound among the five new ruthenium complexes studied in this work, exhibiting an activity comparable to the reference drugs.
Keywords: Ruthenium (II) and (III) lapachol complex
Cytotoxicity
Antileishmanial and antiplasmodial activities
Issue Date: 2014
Publisher: Elsevier Inc
Citation: BARBOSA, M. I. F. et al. Antiparasitic activities of novel ruthenium/lapachol complexes. Journal of Inorganic Biochemistry, v. 136, p. 33-39, 2014.
DOI: 10.1016/j.jinorgbio.2014.03.009
ISSN: 1873-3344
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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