Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8496
Title: Candida species isolated from the vaginal mucosa of HIV-infected women in Salvador, Bahia, Brazil.
Authors: Oliveira, Paula Matos
Mascarenhas, Rita Elizabeth Moreira
Lacroix, Claire
Ferrer, Suzana Ramos
Oliveira, Rone Peterson Cerqueira
Cravo, Elaine Andrade
Alves, André Pinheiro Ribeiro
Grassi, Maria Fernanda Rios
Affilliation: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Laboratoire de Mycologie-Parasitologie. Paris, France
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançadao de Saúde Pública. Salvador, BA, Brasil
Abstract: Background: Vulvovaginal candidiasis (VVC) is the second most common vaginal infection. HIV-infection is a risk factor for this infection. Objective: To determine the frequency of VVC and to describe the main Candida species isolated and their susceptibility to antifungal drugs in HIV-infected patients, compared to HIV-uninfected women in Salvador, Brazil. Methods: Cross-sectional study including a group of 64 HIV-infected women and 76 uninfected women, followed up at the AIDS reference center and at the Gynecological Clinic of Escola Bahiana de Medicina e Saúde Pública (Salvador, Bahia, Brazil). Results: Frequency of Candida spp. was higher in HIV-infected women (29.7%) than in HIV-uninfected controls (14.5%) (p = 0.02). The odds ratio value for vulvovaginal candidiasis in HIV-infected patients was 2.6 (95% CI: 1.07 - 6.32 p = 0.03). Candida albicans was the most commonly isolated species in both HIV-infected (52.3%) and uninfected women (85.7%), followed by C. parapsolis in 17.6% and 14.3%, respectively. In HIV-infected women, C. glabrata, C. parapsilosis, and a coinfection of C. albicans and C. glabrata were also identified. There was no significant difference between Candida species isolated from the vaginal mucosa of women with VVC and colonization of the vaginal mucosa of HIV-infected and HIV-uninfected women. One C. glabrata isolate from an HIV-infected patient was resistant to fluconazole and other two isolates exhibited a dose-dependent susceptibility. Conclusion: Our results confirm a higher frequency of Candida spp. isolated from the vaginal mucosa of HIV-infected women and a broader spectrum of species involved. Only Candida glabrata isolates showed decreased susceptibility to fluconazole.
Keywords: HIV
Candida
Candidiasis
Vulvovaginal
DeCS: Infecções Oportunistas Relacionadas com a AIDS/microbiologia
Candida/isolamento & purificação
Candidíase Vulvovaginal/microbiologia
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico
Adulto
Antifúngicos/farmacologia
Brasil
Candida/classificação
Candida/efeitos de drogas
Candidíase Vulvovaginal/diagnóstico
Feminino
Humanos
Testes de Sensibilidade Microbiana
Membrana Mucosa/microbiologia
Prevalência
Vagina/microbiologia
Issue Date: 2011
Publisher: Elsevier Editora Ltda
Citation: OLIVEIRA, P. M. et al. Candida species isolated from the vaginal mucosa of HIV-infected women in Salvador, Bahia, Brazil. Brazilian Journal of Infectious Diseases, v. 15, n. 3, p. 239-244, 2011.
ISSN: 1678-4391
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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