Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8517
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dc.contributor.authorBastos, Claudilson José de Carvalho
dc.contributor.authorAras Junior, Roque
dc.contributor.authorMota, Gildo de Oliveira
dc.contributor.authorReis, Francisco
dc.contributor.authorDias, Juarez Pereira
dc.contributor.authorJesus, Robson Silva de
dc.contributor.authorFreire, Miralba Silva
dc.contributor.authorAraújo, Eline Gomes de
dc.contributor.authorPrazeres, Juliana Moura Bastos
dc.contributor.authorGrassi, Maria Fernanda Rios
dc.date.accessioned2014-10-06T19:02:57Z
dc.date.available2014-10-06T19:02:57Z
dc.date.issued2010
dc.identifier.citationBASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.
dc.identifier.issn1935-2735
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/8517
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subject.otherDoença de Chagas
dc.subject.otherSurtos de Doenças
dc.subject.otherDoença Aguda
dc.subject.otherAdolescente
dc.subject.otherAdulto
dc.subject.otherEpidemiologia
dc.subject.otherDiagnóstico
dc.subject.otherCriança
dc.titleClinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
dc.typeArticle
dc.identifier.doi10.1371/journal.pntd.0000711
dc.description.abstractenBACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.
dc.creator.affilliationEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
dc.creator.affilliationEpidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
dc.creator.affilliationCouto Maia Hospital. Salvador, BA, Brasil.
dc.creator.affilliationEpidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
dc.creator.affilliationEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
dc.subject.decsDoença de Chagas/quimioterapia
dc.subject.decsSurtos de Doenças
dc.subject.decsDoença Aguda
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsBrasil/epidemiologia
dc.subject.decsDoença de Chagas /diagnóstico
dc.subject.decsDoença de Chagas /epidemiologia
dc.subject.decsCriança
dc.subject.decsEcocardiografia Doppler
dc.subject.decsEletrocardiografia
dc.subject.decsFeminino
dc.subject.decsHumanos
dc.subject.decsMasculino
dc.subject.decsNitroimidazóis /uso terapêutico
dc.subject.decsRadiografia Torácica
dc.subject.decsResultado do Tratamento
dc.subject.decsTripanossomicidas /uso terapêutico
dc.subject.decsTrypanosoma cruzi /isolamento & purificação
Appears in Collections:BA - IGM - Artigos de Periódicos

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