| Author | Gama, Kelly Barbosa | |
| Author | Quintans, Jullyana de Souza Siqueira | |
| Author | Antoniolli, Angelo Roberto | |
| Author | Quintans Junior, Lucindo José | |
| Author | Santana, Wagno Alcântara | |
| Author | Branco, Alexsandro | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Villarreal, Cristiane Flora | |
| Access date | 2014-10-08T19:34:21Z | |
| Available date | 2014-10-08T19:34:21Z | |
| Document date | 2013 | |
| Citation | GAMA, K. B. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Journal of Natural Products, v. 76, n. 4, p. 559-563, 2013. | pt_BR |
| ISSN | 1520-6025 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8554 | |
| Language | eng | pt_BR |
| Publisher | ACS Publications | pt_BR |
| Rights | open access | pt_BR |
| Title | Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1021/np3007342 | |
| Abstract | Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported
pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive
properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice.
Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the
involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5−40
mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice
treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by
naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-
opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+
channel blocker; 2 mg/kg). Systemic administration of 1 (5−40 mg/kg) increased the number of Fos positive cells in the
periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated
by opioid receptors and endogenous analgesic mechanisms | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, Brasil | pt_BR |
| Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, Brasil | pt_BR |
| Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| DeCS | Agave/química | pt_BR |
| DeCS | Analgésicos/farmacologia | pt_BR |
| DeCS | Dor/quimioterapia | pt_BR |
| DeCS | Compostos de Espiro/farmacologia | pt_BR |
| DeCS | Esteroides/farmacologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Glibureto/farmacologia | pt_BR |
| DeCS | Canais KATP/antagonistas & inibidores | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Estrutura Molecular | pt_BR |
| DeCS | Naltrexona/farmacologia | pt_BR |
| DeCS | Substância Cinzenta Periaquedutal/efeitos de drogas | pt_BR |
| DeCS | Folhas de Planta/química | pt_BR |
| DeCS | Receptores Opioides kappa/antagonistas & inibidores | pt_BR |
