Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/856
Title: Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected Brazilian women
Authors: Grinsztejn, Beatriz Gilda Jegerhorn
Santos, Valdiléa Gonçalves Veloso dos
Levi, José Eduardo
Velasque, Luciane
Luz, Paula Mendes
Friedman, Ruth Khalili
Andrade, Angela Cristina Vasconcelos de
Moreira, Ronaldo Ismerio
Russomano, Fabio
Pilotto, Jose Henrique da Silva
Bastos, Francisco Inácio Pinkusfeld Monteiro
Palefsky, Joel
Affilliation: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo, SP, Brasil.
Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz,
Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz,
Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz,
Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz,
Instituto de Pesquisa Clínica Evandro CIhagas (IPEC), Fundação Oswaldo Cruz,
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (ICICT), Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, RJ, Brasil
University of California at San Francisco. San Francisco, CA, USA.
Abstract: Summary Objectives: Human papillomavirus (HPV) infection is a major risk factor for cervical disease. Using baseline data from the HIV-infected cohort of Evandro Chagas Clinical Research Institute at Fiocruz, Rio de Janeiro, Brazil, factors associated with an increased prevalence of HPV were assessed. Methods: Samples from 634 HIV-infected women were tested for the presence of HPV infection using hybrid capture II and polymerase chain reaction. Prevalence ratios (PR) were estimated using Poisson regression analysis with robust variance. Results: The overall prevalence of HPV infection was 48%, of which 94% were infected with a high-risk HPV. In multivariate analysis, factors independently associated with infection with highrisk HPV type were: younger age (<30 years of age; PR 1.5, 95% confidence interval (CI) 1.1—2.1), current or prior drug use (PR 1.3, 95% CI 1.0—1.6), self-reported history of HPV infection (PR 1.2, 95% CI 0.96—1.6), condom use in the last sexual intercourse (PR 1.3, 95% CI 1.1—1.7), and nadir CD4+ T-cell count <100 cells/mm3 (PR 1.6, 95% CI 1.2—2.1). Conclusions: The estimated prevalence of high-risk HPV-infection among HIV-infected women from Rio de Janeiro, Brazil, was high. Close monitoring of HPV-related effects is warranted in all HIVinfected women, in particular those of younger age and advanced immunosuppression.
Keywords: Human papillomavirus
Human immunodeficiency virus
Evandro Chagas Research Institute cohort
Prevalence ratio
Brazil
Issue Date: 2009
Publisher: Elsevier B.V
Citation: International Journal of Infectious Diseases, v.13, n.5, p.72-80, 2009.
ISSN: 1201-9712
Copyright: open access
Appears in Collections:ICICT - Artigos de Periódicos

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