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Title: Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men.
Authors: Goldstone, Stephen
Palefsky, Joel M
Giuliano, Anna R
Moreira Júnior, Edson Duarte
Aranda, Carlos
Jessen, Heiko
Hillman, Richard J
Ferris, Daron G
Coutlee, Francois
Liaw, Kai-Li
Marshall, J. Brooke
Zhang, Xuehong
Vuocolo, Scott
Barr, Eliav
Haupt, Richard M
Guris, Dalya
Garner, Elizabeth I. O
Affilliation: Mount Sinai School of Medicine. New York, New York
University of California San Francisco. Department of Medicine. San Francisco, California
Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center. Tampa, Florida / Research Institute. Tampa, Florida
Associação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University Medical Center. National Public Health Institute. Morelos, Mexico
J2: Private Clinic for Infectious Diseases. Berlin, Germany
University of Sydney. STI Research Centre.Sydney, Australia
Gynecologic Cancer Prevention Center. Medical College of Georgia. Augusta, Georgia
Université de Montre´al,Montreal. Centre de recherche du CHUM. Quebec, Canada
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Harvard School of Public Health. Departments of Epidemiology and Nutrition. Boston, Massachusetts
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Abstract: BACKGROUND: We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). METHODS: Data were analyzed from 602 MSM aged 16-27 years with ≤ 5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. RESULTS: The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. CONCLUSIONS: The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection
DeCS: Doenças do Ânus/epidemiologia
Doenças dos Genitais Masculinos/epidemiologia
Homossexualidade Masculina
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/epidemiologia
Canal Anal/virologia
Anticorpos Antivirais/sangue
Doenças do Ânus/virologia
DNA Viral/genética
DNA Viral/isolamento & purificação
Europa (Continente)
Doenças dos Genitais Masculinos/virologia
América Latina
Infecções por Papillomavirus/virologia
Fatores de Risco
Issue Date: 2011
Publisher: Oxford University Press
Citation: GOLDSTONE, S. et al. Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. Journal of Infectious Diseases, v. 203, n. 1, p. 66-74, 2011.
DOI: 10.1093/infdis/jiq016
ISSN: 1537-6613
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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