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dc.contributor.authorSilva, Larissa Lopes
dc.contributor.authorMarcet-Houben, Marina
dc.contributor.authorZerlotini, Adhemar
dc.contributor.authorGabaldón, Toni
dc.contributor.authorOliveira, Guilherme Corrêa
dc.contributor.authorNahum, Laila Alves
dc.date.accessioned2015-01-07T11:37:04Z
dc.date.available2015-01-07T11:37:04Z
dc.date.issued2011
dc.identifier.citationSILVA, Larissa Lopes et al. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 77-864, 2011
dc.identifier.issn0074-0276
dc.identifier.issnhttp://dx.doi.org/10.1590/S0074-02762011000700013
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/9340
dc.language.isoeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.titleEvolutionary histories of expanded peptidase families in Schistosoma mansoni
dc.typeArticle
dc.description.abstractenSchistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main virulence factors involved in the pathogenesis of this disease. In this context, evolutionary studies can be applied to identify peptidase families that have been expanded in genomes over time in response to different selection pressures. Using a phylogenomic approach, we searched for expanded endopeptidase families in the S. mansoni predicted proteome with the aim of contributing to the knowledge of such enzymes as potential therapeutic targets. We found three endopeptidase families that comprise leishmanolysins (metallopeptidase M8 family), cercarial elastases (serine peptidase S1 family) and cathepsin D proteins (aspartic peptidase A1 family). Our results suggest that the Schistosoma members of these families originated from successive gene duplication events in the parasite lineage after its diversification from other metazoans. Overall, critical residues are conserved among the duplicated genes/proteins. Furthermore, each protein family displays a distinct evolutionary history. Altogether, this work provides an evolutionary view of three S. mansoni peptidase families, which allows for a deeper understanding of the genomic complexity and lineage-specific adaptations potentially related to the parasitic lifestyle.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil
dc.creator.affilliationUniversitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, Spain
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
dc.creator.affilliationUniversitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, Spain
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
dc.subject.enphylogenomics
dc.subject.enmaximum likelihood analysis
dc.subject.enhomology prediction
dc.subject.enfunctional annotation
dc.subject.enproteases
dc.subject.enparalogous families
dc.subject.enparasite genomics
Appears in Collections:MG - IRR - Artigos de Periódicos

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