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SÍNTESE, CARACTERIZAÇÃO E ESTUDO DA ATIVIDADE INIBITÓRIA DE NOVAS DIALQUIFOSFORILARILIDRAZONAS SOBRE O CRESCIMENTO DE TRIPANOSSOMATÍDEOS
Doença de Chagas
Dialquilfosforilarilidrazonas
Tripanossomíase Americana
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Abstract
A new series of dialkylphosphorylhydrazones was synthesized through the condensation of aromatic aldehydes with different phosphorylhydrazines. All synthesized compounds were characterized
by IR, 1H-NMR, 13C-NMR and 31P-NMR spectroscopies. The in vitro investigation of the activity of these compounds against
Leishmania amazonensis promastigotes and epimastigotes of T. cruzi, showed an efficient inhibition of proliferation, at non
toxic concentrations to mammalian cells. The results have shown some derivatives as potential antiparasitic agents against
trypanosomatids
Keywords in Portuguese
LeishmanioseDoença de Chagas
Dialquilfosforilarilidrazonas
Tripanossomíase Americana
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