Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.

College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil

Abstract

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.

DeCS

Citocinas/genética
Regulação da Expressão Gênica
Interleucina-6/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Suscetibilidade a Doenças/imunologia
Regulação para Baixo
Interleucina-6/genética
Leishmaniose Cutânea/genética
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Células Th1/imunologia

Publisher

American Society for Microbiology

Citation

TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.

DOI

10.1128/IAI.69.8.5189–5192.2001

ISSN

0104-5695

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9911

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