Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9931
Title: Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
Authors: Soares, Milena Botelho Pereira
Gonçalves, Renata
Pyrrho, Alexandre dos Santos
Costa, Deise de Andrade
Paiva, Claudia Neto
Gattass, Cerli Rocha
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Abstract: We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-gamma and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.
Keywords: Trypanosoma cruzi
Protection
Cytokines
Humoral response
DeCS: Anticorpos Antiprotozoários/imunologia
Citocinas/biossíntese
Trypanosoma cruzi/imunologia
Animais
Citocinas/sangue
Imunização
Interferon gama/biossíntese
Interferon gama/sangue
Interleucina-2/biossíntese
Camundongos
Camundongos Endogâmicos BALB C
Issue Date: 2003
Publisher: Academia Brasileira de Ciências
Citation: SOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003.
ISSN: 0001-3765
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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