Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9931
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dc.contributor.authorSoares, Milena Botelho Pereira
dc.contributor.authorGonçalves, Renata
dc.contributor.authorPyrrho, Alexandre dos Santos
dc.contributor.authorCosta, Deise de Andrade
dc.contributor.authorPaiva, Claudia Neto
dc.contributor.authorGattass, Cerli Rocha
dc.date.accessioned2015-04-08T16:51:46Z
dc.date.available2015-04-08T16:51:46Z
dc.date.issued2003
dc.identifier.citationSOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003.
dc.identifier.issn0001-3765
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/9931
dc.language.isoeng
dc.publisherAcademia Brasileira de Ciências
dc.rightsopen access
dc.titleBalanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
dc.typeArticle
dc.description.abstractenWe have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-gamma and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enProtection
dc.subject.enCytokines
dc.subject.enHumoral response
dc.subject.decsAnticorpos Antiprotozoários/imunologia
dc.subject.decsCitocinas/biossíntese
dc.subject.decsTrypanosoma cruzi/imunologia
dc.subject.decsAnimais
dc.subject.decsCitocinas/sangue
dc.subject.decsImunização
dc.subject.decsInterferon gama/biossíntese
dc.subject.decsInterferon gama/sangue
dc.subject.decsInterleucina-2/biossíntese
dc.subject.decsCamundongos
dc.subject.decsCamundongos Endogâmicos BALB C
Appears in Collections:BA - IGM - Artigos de Periódicos

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