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Issue DateTitleAuthor(s)CopyrightType
20174-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infectionCalvet, Claudia Magalhaes; Choi, Jun Yong; Thomas, Diane; Suzuki, Brian; Hirata, Ken; Lostracco-Johnson, Sharon; Mesquita, Liliane Batista de; Nogueira, Alanderson; Batista, Marcelo Meuser; Silva, Tatiana Araujo; Siqueira Neto, Jair Lage; Roush, William R.; Pereira, Mirian Claudia de Souza; McKerrow, James H.; Podust, Larissa M.open accessArticle
2016Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruziHoekstra, William J.; Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Batista, Denise da Gama Jaen; Silva, Cristiane F. da; Nefertiti, Aline S. G.; Rachakonda, Girish; Schotzinger, Robert J.; Villalta, Fernando; Soeiro, Maria de Nazaré C.; Lepesheva, Galina I.open accessArticle
2011Trypanosoma cruzi infection induces a global host cell response in cardiomyocytesManque, Patricio A.; Probst, Christian M.; Probst, Christian; Pereira, Mirian C. S.; Rampazzo, Rita C. P.; Ozaki, Luiz Shozo; Ozaki, L. Shozo; Pavoni, Daniela P.; Silva Neto, Dayse T.; Carvalho, M. Ruth; Xu, Ping; Serrano, Myrna G.; Alves, João M. P.; Meirelles, Maria de Nazareth S. L.; Goldenberg, Samuel; Krieger, Marco A.; Buck, Gregory A.open accessArticle
2012A novel triazolic naphthofuranquinone induces autophagy in reservosomes and impairment of mitosis in Trypanosoma cruziFernandes, M. C.; Silva, E. N. da; Pinto, A. V.; Castro, S. L. de; Menna-Barreto, R. F. S.restricted accessArticle
2012Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parametersSilva, Diana Rodrigues da; Castro, Solange Lisboa de; Alves, Monique Castro da Silva; Batista, Wanderson da Silva; Oliveira, Gabriel Melo deopen accessArticle
2013Effects of a marine serine protease inhibitor on viability and morphology of Trypanosoma cruzi, the agent of Chagas diseaseNogueira, Natália Pereira de Almeida; Morgado-Díaz, José Andrés; Menna-Barreto, Rubem Figueiredo Sadok; Paes, Marcia Cristina; López, Raquel Elisa da Silvarestricted accessArticle
2017Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas DiseaseNascimento, Clarissa R.; Andrade, Daniele; Pinto, Carla Eponina; Serra, Rafaela Rangel; Vellasco, Lucas; Brasil, Guilherme; Ramos Junior, Erivan Schnaider; Mota, Julia Barbalho da; Almeida, Larissa Nogueira; Andrade, Marcus V.; Soeiro, Maria de Nazaré Correia; Juliano, Luiz; Alvarenga, Patrícia Hessab; Oliveira, Ana Carolina; Sicuro, Fernando Lencastre; Carvalho, Antônio C. Campos de; Svensjö, Erik; Scharfstein, Julioopen accessArticle
2010A proteomic analysis of the mechanism of action of naphthoimidazoles in Trypanosoma cruzi epimastigotes in vitroMenna Barreto, Rubem F. S.; Beghini, Daniela G.; Ferreira, André T. S.; Pinto, Antônio V.; Castro, Solange L. de; Perales, Jonasrestricted accessArticle
2012Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Gunatilleke, Shamila S.; Calvet, Claudia M. d'Avila; Johnston, Jonathan B.; Chen, Chiung-Kuang; Erenburg, Grigori; Gut, Jiri; Engel, Juan C.; Ang, Kenny K. H.; Mulvaney, Joseph; Chen, Steven; Arkin, Michelle R.; McKerrow, James H.; Podust, Larissa M.open accessArticle
2010Developmental and reproductive patterns of Triatoma brasiliensis infected with Trypanosoma cruzi under laboratory conditionsOliveira, Tiago G.; Costa, Filipe A. Carvalho; Gomes, Taís F.; Sarquis, Otília; Sposina, Ricardo; Lima, Marli M.open accessArticle