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https://www.arca.fiocruz.br/handle/icict/10781
FLOWER CELLSIN PATIENT SWITH INFECTIVE DERMATITIS ASSOCIATED WITH HTLV-1
Infective dermatitisassociatedwithHTLV-1
Adult T-cellleukemia/lymphoma
Flower cells
Skin diseasescausedbyHTLV-1
Infecções por HTLV-I/diagnóstico
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Linfócitos/patologia
Dermatopatias Virais/diagnóstico
Adolescente
Sangue/virologia
Criança
Pré-Escolar
Sangue/virologia
Feminino
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Humanos
Masculino
Reação em Cadeia da Polimerase
Provirus/genética
Provirus/isolamento & purificação
Author
Affilliation
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Internal Medicine. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Internal Medicine. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil
Abstract
BACKGROUND: Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL). OBJECTIVE: In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH. STUDY DESIGN: Over a period of 33 months, the patients were submitted to three-monthly clinical evaluations, routine laboratory exams, full blood count and blood smears, and to six-monthly blood sampling for HTLV-1 proviral load determination. HTLV-1 proviral load was quantified using real-time TaqMan PCR assay. RESULTS: Abnormal cells (Ably) were found in the peripheral blood smears of nine patients (30%), flower cells being detected in five of these cases (16.6%). The presence of Ably and flower cells was not associated with a higher proviral load in those patients. CONCLUSIONS: This is the first report on the presence of flower cells in HTLV-1-infected children and adolescents. Furthermore, these cells have not previously been reported in IDH patients. The cases with flower cells probably represent precursory ATL cases, these patients being at a greater risk of developing ATL.
Keywords
HTLV-1 infectionInfective dermatitisassociatedwithHTLV-1
Adult T-cellleukemia/lymphoma
Flower cells
Skin diseasescausedbyHTLV-1
DeCS
Dermatite/virologiaInfecções por HTLV-I/diagnóstico
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Linfócitos/patologia
Dermatopatias Virais/diagnóstico
Adolescente
Sangue/virologia
Criança
Pré-Escolar
Sangue/virologia
Feminino
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Humanos
Masculino
Reação em Cadeia da Polimerase
Provirus/genética
Provirus/isolamento & purificação
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