Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/13738
MOLECULAR CHARACTERIZATION OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN WOMEN AND THEIR VERTICALLY INFECTED CHILDREN
Author
Affilliation
Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil / National Institute of Health. Department of Infectious, Parasitic and Immunomediated Diseases. Rome, Italy
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa
University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa
Specialized Center in Diagnosis. Care and Research. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil / National Institute of Health. Department of Infectious, Parasitic and Immunomediated Diseases. Rome, Italy
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa
University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa
Specialized Center in Diagnosis. Care and Research. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil
Abstract
Approximately 35 million people worldwide are infected with human immunodeficiency virus (HIV) around 3.2 million of whom are children under 15 years. Mother-to-child-transmission (MTCT) of HIV-1 accounts for 90% of all infections in children. Despite great advances in the prevention of MTCT in Brazil, children are still becoming infected. Samples from 19 HIV-1-infected families were collected. DNA was extracted and fragments from gag, pol, and env were amplified and sequenced directly. Phylogenetic reconstruction was performed. Drug resistance analyses were performed in pol and env sequences. We found 82.1% of subtype B and 17.9% of BF recombinants. A prevalence of 43.9% drug resistance-associated mutations in pol sequences was identified. Of the drug-naive children 33.3% presented at least one mutation related to protease inhibitor/nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor (PI/NRTI/NNRTI) resistance. The prevalence of transmitted drug resistance mutations was 4.9%. On env we found a low prevalence of HR1 (4.9%) and HR2 (14.6%) mutations
Share