Author | Amor, Ana Lúcia Moreno | |
Author | Santos, Leonardo Nascimento | |
Author | Galvão, Alana Alcântara | |
Author | Belitardo, Emília Maria Medeiros de Andrade | |
Author | Silva, Eduardo Santos | |
Author | Neves, Neuza Maria Alcântara | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Access date | 2016-08-31T17:41:01Z | |
Available date | 2016-08-31T17:41:01Z | |
Document date | 2014 | |
Citation | AMOR, A. L. M. et al. Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy. Immunotherapy, v. 6, n.12, p. 1255-1264, 2014. | pt_BR |
ISSN | 1750-743X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15564 | |
Language | eng | pt_BR |
Publisher | Future Medicine | pt_BR |
Rights | open access | pt_BR |
Title | Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy | pt_BR |
Type | Article | pt_BR |
DOI | 10.2217/imt.14.89 | |
Abstract | This study's objective was to investigate whether candidin or trichophytin elicit recall immune responses that could potentially inhibit a Th2 response. MATERIALS & METHODS: Peripheral blood mononuclear cells from nine allergic and seven nonallergic individuals were cultivated in vitro in the presence or absence of these fungal extracts. RESULTS: Trichophytin or candidin, or both, stimulated the production of regulatory cytokines (TGF-β and/or IL-10), accompanied or not by stimulation of production of cytokines associated with the Th1 response (TNF-α, IL-12 and IFN-γ), but without stimulation of Th2 cytokines (IL-5 and IL-13) and IL-17, by peripheral blood mononuclear cells of most allergic and nonallergic individuals. CONCLUSION: These results indicate that these fungal extracts could be used as adjuvants in personalized therapeutic vaccines in a fair proportion of individuals. In addition, they justify the carrying out of investigations aimed at identifying molecules in these extracts that might exclusively induce Treg and/or Th1 immune responses. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Campus do Governo. Santo Antônio de Jesus, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Candidin | pt_BR |
Subject | Cytokine | pt_BR |
Subject | Immune response | pt_BR |
Subject | Immunotherapy | pt_BR |
Subject | Trichophytin | pt_BR |