Author | Brunoro, Giselle Villa Flor | |
Author | Faça, Vitor Marcel | |
Author | Caminha, Marcelle Almeida | |
Author | Ferreira, André Teixeira da Silva | |
Author | Trugilho, Monique | |
Author | Moura, Kelly Cristina Gallan de | |
Author | Perales, Jonas | |
Author | Valente, Richard Hemmi | |
Author | Menna-Barreto, Rubem Figueiredo Sadok | |
Access date | 2016-12-08T16:27:35Z | |
Available date | 2016-12-08T16:27:35Z | |
Document date | 2016 | |
Citation | BRUNORO, Giselle Villa Flor; et al. Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes. PLoS Negl Trop Dis., v.10, n.8, e0004951., 18p, 2016. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16491 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | América Latina | pt_BR |
Subject in Portuguese | Tripomastigotas da corrente sanguínea | pt_BR |
Subject in Portuguese | Eletroforese em Gel | pt_BR |
Title | Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0004951 | |
Abstract | The obligate intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness affecting millions of people in Latin America that recently entered non-endemic countries through immigration, as a consequence of globalization. The chemotherapy for this disease is based mainly on benznidazole and nifurtimox, which are very efficient nitroderivatives against the acute stage but present limited efficacy during the chronic phase. Our group has been studying the trypanocidal effects of naturally occurring quinones and their derivatives, and naphthoimidazoles derived from β-lapachone N1, N2 and N3 were the most active. To assess the molecular mechanisms of action of these compounds, we applied proteomic techniques to analyze treated bloodstream trypomastigotes, which are the clinically relevant stage of the parasite. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Gel Electrophoresis (DIGE) | pt_BR |
Subject | Naphthoimidazoles | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Bloodstream Trypomastigotes | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Latin America | pt_BR |
e-ISSN | 1935-2735) | |