Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/17845
Title: Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation
Authors: Mathad, Jyoti S.
Gupte, Nikhil
Balagopal, Ashwin
Asmuth, David
Hakim, James
Santos, Breno
Riviere, Cynthia
Hosseinipour, Mina
Sugandhavesa, Patcharaphan
Infante, Rosa
Pillay, Sandy
Cardoso, Sandra W.
Mwelase, Noluthando
Pawar, Jyoti
Berendes, Sima
Kumarasamy, Nagalingeswaran
Andrade, Bruno B.
Campbell, Thomas B.
Currier, Judith S.
Cohn, Susan E.
Gupta, Amita
Affilliation: Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. New York, NY, USA.
Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Division of Infectious Diseases. Baltimore, USA.
Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India
University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA.
University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA.
Hospital Nossa Senhora de Conceição. Divisão de Doenças Infecciosas. Porto Alegre, RS, Brasil.
Les Centres GHESKIO. Port-Au-Prince, Haiti.
University of North Carolina-Lilongwe. Department of Medicine. Lilongwe, Malawi.
Research Institute for Health Sciences. Chiang Mai, Thailand.
Impacta Peru. San Miguel, Peru.
Durban University of Technology. Durban International Clinical Research Site. Durban, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. STD/AIDS Clinical Research Laboratory. Rio de Janeiro, RJ, Brasil.
University of Witwatersrand. Department of Medicine. Johannesburg, South Africa.
National AIDS Research Institute (ICMR). Pune, India.
Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi.
Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Departamento de Medicina de Investigações. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil.
University of Colorado-Denver. Division of Infectious Diseases, Aurora, CO, USA.
University of California Los Angeles. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.
Northwestern University Feinberg School of Medicine. Division of Infectious Diseases. Chicago, USA.
Abstract: Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon g, tumor necrosis factor (TNF) a, IL-6, IL-18, IFN-g–induced protein 10, C-reactive protein (CRP), lipopolysaccharide, and sCD14] were measured at weeks 0, 24, and 48 after combination antiretroviral therapy (cART) in a random subcohort (n = 215) who achieved virologic suppression in ACTG A5175 (Prospective Evaluation of Antiretrovirals in Resource-Limited Settings). Association between sex and changes in markers postcART was examined using random effects models. Average marker differences and 95% confidence intervals were estimated using multivariable models. Results: At baseline, women had lower median log10 viral load (4.93 vs 5.18 copies per milliliter, P = 0.01), CRP (2.32 vs 4.62 mg/L, P =0.01), detectable lipopolysaccharide (39% vs 55%, P = 0.04), and sCD14 (1.9 vs 2.3 mg/mL, P = 0.06) vs men. By week 48, women had higher interferon g (22.4 vs 14.9 pg/mL, P = 0.05), TNF-a (11.5 vs 9.5pg/mL, P = 0.02), and CD4 (373 vs 323 cells per cubic millimeter, P =0.02). In multivariate analysis, women had greater increases in CD4 and TNF-a but less of a decrease in CRP and sCD14 compared with men. Conclusions: With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality.
Keywords: HIV
Inflammation
Immune activation
Sex
Women
Antiretroviral treatment
keywords: HIV
Inflamação
Ativação imunológica
Sexo
Mulheres
Tratamento antiretroviral
DeCS: HIV
Comportamento Sexual
Issue Date: 2016
Publisher: Lippincott, Williams & Wilkins
Citation: MATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal Acquir. Immune Defic. Syndr., v. 73, p. 123–129, 2016.
Description: The authors thank the Prospective Evaluation of Antiretrovirals in Resource-Limited Setting study participants for volunteering their time and efforts.
DOI: 10.1097/QAI.0000000000001095
ISSN: 1077-9450
Copyright: restricted access
Appears in Collections:CPqGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
ve_Jyoti_Mathad_etal_CPqGM_2016.pdf330.17 kBAdobe PDFView/Open    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.