Author | Guimarães, Luiz Henrique Santos | |
Author | Queiroz, Adriano | |
Author | Silva, Juliana Almeida da | |
Author | Silva, Silvana Conceição da | |
Author | Andrade, Viviane Magalhães | |
Author | Lago, Ednaldo L | |
Author | Machado, Paulo Roberto Lima | |
Author | Bacellar, Maria Olívia Amado Ramos | |
Author | Wilson, Mary E | |
Author | Beverley, Stephen M | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Schriefer, Nicolaus Albert Borges | |
Access date | 2017-03-23T18:22:19Z | |
Available date | 2017-03-23T18:22:19Z | |
Document date | 2016 | |
Citation | GUIMARÃES, L. H. S. et al. Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects. PLoS Neglected Tropical Disease, v. 10, n. 12, p. e0005100, 2016. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18157 | |
Sponsorship | U.S. National Institutes of Health (NIH), through grants NIH P50-AI30639-16 and NIH R03A167663-01. LHG was the recipient of a CAPES. | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
Subject in Portuguese | Leishmania Braziliensis | pt_BR |
Subject in Portuguese | Imunologia | pt_BR |
Subject in Portuguese | Parasitologia | pt_BR |
Subject in Portuguese | Brazil | pt_BR |
Title | Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0005100 | |
Abstract | Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. Methodology/Principal Findings
Between 2005 and 2012, 51 ACL (cases) and 51 temporally matched cutaneous leishmaniasis
(CL) subjects (controls) were enrolled and followed over time in Corte de Pedra. Clinical
and therapeutic data were recorded for all subjects. Cytokine secretion by patients' peripheral
blood mononuclear cells (PBMC) stimulated with soluble parasite antigen in vitro, and genotypes
in a 600 base-pair locus in chromosome 28 (CHR28/425451) of the infecting L. (V.) braziliensis
were compared between the two groups. ACL presented significantly more lesions in
head and neck, and higher rate of antimony failure than CL. Cytosine±Adenine substitutions
at CHR28/425451 positions 254 and 321 were highly associated with ACL (p<0.0001). In vitro
stimulated ACL PBMCs produced lower levels of IFN-γ (p = 0.0002) and TNF (p <0.0001),
and higher levels of IL-10 (p = 0.0006) and IL-17 (p = 0.0008) than CL PBMCs.
Conclusions/Significance
ACL found in Northeast Brazil is caused by distinct genotypes of L. (V.) braziliensis and
presents a cytokine profile that departs from that in classical CL patients. We think that differences in antigenic contents among parasites may be in part responsible for the variation
in cytokine responses and possibly immunopathology between CL and ACL | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil / Universidade Federal do Sul da Bahia. Centro de Formação em Saúde. Teixeira de Freitas, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil | pt_BR |
Affilliation | University of Iowa. Department of Internal Medicine. Iowa City, Iowa, USA / University of Iowa. Department of Microbiology. Iowa City, Iowa, USA / VA Medical Center. Iowa City, Iowa, USA | pt_BR |
Affilliation | University School of Medicine. Department of Molecular Microbiology. Washington, Missouri, USA | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil | pt_BR |
Subject | Cutaneous Leishmaniasis | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Immunology | pt_BR |
Subject | Parasitology | pt_BR |
Subject | Brazil | pt_BR |