Author | Gadelha, Sandra Rocha | |
Author | Alcantara, Luiz Carlos Júnior | |
Author | Costa, Giselle Calasans de Souza | |
Author | Acosta, Angelina Xavier | |
Author | Rios, Domingos | |
Author | Kashima, Simone G | |
Author | Covas, Dimas Tadeu | |
Author | Castro Filho, Bernardo Galvão | |
Date | 2008 | |
Access date | 2011-04-12T22:21:50Z | |
Available date | 2011-04-12T22:21:50Z | |
Document date | 2008 | |
Citation | GADELHA, S. R. et al. Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. Journal of Medical Virology, v.80, n.12, p.2141-2146, 2008. | |
ISSN | 0146-6615 | |
URI | https://www.arca.fiocruz.br/handle/icict/1891 | |
Language | eng | pt_BR |
Rights | open access | en |
Title | Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jmv.21341 | |
Abstract | HTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: -174, -572, -597, and -634 positions, and IL-10: -592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The -634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the -174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the -634GC/-174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only -634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60-17.56; P = 0.006). We suggest that -634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease. | pt_BR |
Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
Affilliation | Laboratório de Genética Molecular, Departamento de Ciências Biológicas (DCB), Universidade Estadual do Sudoeste da Bahia (UESB), Bahia, Brasil | pt_BR |
Affilliation | Hemocentro de Ribeirão Preto, São Paulo, Brasil | pt_BR |
Affilliation | Hemocentro de Ribeirão Preto, São Paulo, Brasil | pt_BR |
Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Interleukin-6 | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | Polymorphisms | pt_BR |
Subject | Brazilian populations | pt_BR |
DeCS | Infecções por HTLV-I | pt_BR |
DeCS | Interleucina-6 | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Paraparesia Espástica Tropical | pt_BR |
DeCS | Polimorfismo de Um Único Nucleotídeo | pt_BR |
DeCS | Regiões Promotoras Genéticas | pt_BR |
DeCS | Doenças da Medula Espinal | pt_BR |