Author | Santos, Théo Araújo | |
Author | Andrade, Bruno de Bezerril | |
Author | Santana, Leonardo Gil | |
Author | Luz, Nívea Farias | |
Author | Santos, Priscila Lima dos | |
Author | Oliveira, Fabrícia A. de | |
Author | Almeida, Meirielly Lima | |
Author | Campos, Roseane Nunes de Santana | |
Author | Bozza, Patrícia Torres | |
Author | Almeida, Roque Pacheco de | |
Author | Borges, Valeria de Matos | |
Access date | 2017-07-10T18:37:39Z | |
Available date | 2017-07-10T18:37:39Z | |
Document date | 2017 | |
Citation | SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20030 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho
Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5
and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de
Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01). | pt_BR |
Language | eng | pt_BR |
Publisher | Nature Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose visceral | pt_BR |
Subject in Portuguese | Biomarcadores | pt_BR |
Subject in Portuguese | Saúde pública | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Title | Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-017-04595-8 | |
Abstract | Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1), IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α compared with uninfected endemic control group, while exhibiting decreased levels of TGF-β1. Hierarchical cluster analysis of the prospective changes in the expression level of theses parameters upon anti-Leishmania treatment initiation revealed that the inflammatory profile observed in active disease gradually changed over time and was generally reversed at day 30 of therapy. Furthermore, not only the individual concentrations of most of the inflammatory biomarkers changed upon treatment, but the correlations between those and several biochemical parameters used to characterize VL disease activity were also modified over time. These results demonstrate that an inflammatory imbalance hallmarks active VL disease and open perspective for manipulation of these pathways in future studies examining a potential host-directed therapy against VL. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro das Ciências Biológicas e da Saúde. Barreiras, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. UNIFACS. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Subject | Visceral leishmaniasis | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Public health | pt_BR |
Subject | Treatment | pt_BR |
Subject | Inflammation | pt_BR |