Author | Fernandes, Jamille Souza | |
Author | Araujo, Maria Ilma | |
Author | Lopes, Diego Mota | |
Author | Souza, Robson da Paixão de | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Cardoso, Luciana Santos | |
Access date | 2018-02-23T13:36:52Z | |
Available date | 2018-02-23T13:36:52Z | |
Document date | 2014 | |
Citation | FERNANDES, J. S. et al. Monocyte subsets in schistosomiasis patients with periportal fibrosis. Mediators of Inflammation, ID 703653, 2014. | pt_BR |
ISSN | 0962-9351 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24924 | |
Description | CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was supported by the Brazilian National Research Council (CNPq) Universal (482113/2010-3). | pt_BR |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Esquistossomose | pt_BR |
Subject in Portuguese | Fibrose | pt_BR |
Subject in Portuguese | Monócitos | pt_BR |
Subject in Portuguese | Cirrose hepática | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Adulto | pt_BR |
Title | Monocyte subsets in schistosomiasis patients with periportal fibrosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2014/703653 | |
Abstract | A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)). The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R) between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
Subject | Schistosomiasis | pt_BR |
Subject | Fibrosis | pt_BR |
Subject | Monocytes | pt_BR |
Subject | Liver Cirrhosis | pt_BR |
Subject | Humans | pt_BR |
Subject | Adult | pt_BR |