Author | Moura, Ana Rafaela Silva Simões | |
Author | Kretz, Cécilia Batmalle | |
Author | Ferreira, Ítalo Eustáquio | |
Author | Nunes, Amélia Maria Pithon Borges | |
Author | Filippis, Ivano de | |
Author | Moraes, José Cássio de | |
Author | Reis, Mitermayer Galvão dos | |
Author | McBride, Alan John Alexander | |
Author | Wang, Xin | |
Author | Campos, Leila Carvalho | |
Access date | 2018-04-20T13:27:05Z | |
Available date | 2018-04-20T13:27:05Z | |
Document date | 2018 | |
Citation | MOURA, A. R. S. S. et al. Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil. International Journal of Medical Microbiology, 2018. | pt_BR |
ISSN | 1438-4221 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25978 | |
Sponsorship | Ministério da Saúde, Brazil (grant number TC335/2013), and Fundação de Amparo à Pesquisa do Estado
da Bahia (grant number SUS 007/2014). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Neisseria lactamica | pt_BR |
Subject in Portuguese | Neisseria meningitidis | pt_BR |
Subject in Portuguese | Transporte orofaríngeo | pt_BR |
Subject in Portuguese | Vacinas | pt_BR |
Title | Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ijmm.2018.03.007 | |
Abstract | Neisseria lactamica is a nonpathogenic commensal bacterium that is potentially associated with the development of natural immunity against N. meningitidis. However, the genetic variation present in natural populations of N. lactamica has not been fully investigated. To better understand its epidemiology and genetic variation, we studied N. lactamica carriage in 1200 students aged 11-19 years old in Salvador, Brazil. The carriage prevalence was 4.5% (54/1200), with no statistical difference among sex and age, although we observed a trend towards higher carriage prevalence among 11-year-old individuals. Whole genome sequence analysis revealed a high genetic diversity among the isolates, with the presence of 32 different STs, 28 (87.5%) of which were new. A total of 21/50 (42%) isolates belonged to three different clonal complexes. While none of the isolates contained nadA or fHpb alleles, we detected 21 FetA variants, 20 NhbA variants and two variants of PorB. The data provide detailed information on circulating N. lactamica isolates in adolescents in Brazil and are complementary to studies in other countries. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Centers for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta GA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Santa Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico. Núcleo de Biotecnologia. Pelotas, RS, Brasil | pt_BR |
Affilliation | Centers for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta GA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Subject | Neisseria lactamica | pt_BR |
Subject | Neisseria meningitidis | pt_BR |
Subject | Oropharyngeal carriage | pt_BR |
Subject | Vaccines | pt_BR |