Author | Valdivia, Hugo Oswaldo | |
Author | Almeida, Laila Vieira | |
Author | Roatt, Bruno Mendes | |
Author | Cunha, João Luís Reis | |
Author | Pereira, Agnes Antônia Sampaio | |
Author | Gontijo, Celia Maria Ferreira | |
Author | Fujiwara, Ricardo Toshio | |
Author | Reis, Alexandre Barbosa | |
Author | Sanders, Mandy J. | |
Author | Cotton, James A. | |
Author | Bartholomeu, Daniella Castanheira | |
Access date | 2018-06-06T18:25:39Z | |
Available date | 2018-06-06T18:25:39Z | |
Document date | 2017 | |
Citation | VALDIVIA, Hugo Oswaldo et al. Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil. Sci Rep., v. 7, 40804, 2017 | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26752 | |
Language | eng | pt_BR |
Publisher | Nature Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | vetores | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Title | Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/srep40804 | |
Abstract | Leishmaniasis is a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania. These parasites are taxonomically diverse, with human pathogenic species separated into two subgenera according to their development site inside the alimentary tract of the sand fly insect vector. The disease encompasses a variable spectrum of clinical manifestations with tegumentary or visceral symptoms. Among the causative species in Brazil, Leishmania (Leishmania) amazonensis is an important etiological agent of human cutaneous leishmaniasis that accounts for more than 8% of all cases in endemic regions. L. (L.) amazonensis is generally found in the north and northeast regions of Brazil. Here, we report the first isolation of L. (L.) amazonensis from dogs with clinical manifestations of visceral leishmaniasis in Governador Valadares, an endemic focus in the southeastern Brazilian State of Minas Gerais where L. (L.) infantum is also endemic. These isolates were characterized in terms of SNPs, chromosome and gene copy number variations, confirming that they are closely related to a previously sequenced isolate obtained in 1973 from the typical Northern range of this species. The results presented in this article will increase our knowledge of L. (L.) amazonensis-specific adaptations to infection, parasite survival and the transmission of this Amazonian species in a new endemic area of Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Peru | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Wellcome Trust Sanger Institute. Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK | pt_BR |
Affilliation | Wellcome Trust Sanger Institute. Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Peru | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | vectores | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Embargo date | 2020-01-01 | |