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https://www.arca.fiocruz.br/handle/icict/2767
EVALUATION OF FOUR WHOLE-CELL LEPTOSPIRA-BASED SEROLOGICAL TESTS FOR DIAGNOSIS OF URBAN LEPTOSPIROSIS
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Royal Tropical Institute (KIT). Department of Biomedical Research. Amsterdam, The Netherlands
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Cornell University. Weill Medical College. Division of International Medicine and Infectious Disease. New York, NY, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Royal Tropical Institute (KIT). Department of Biomedical Research. Amsterdam, The Netherlands
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Cornell University. Weill Medical College. Division of International Medicine and Infectious Disease. New York, NY, USA
Abstract
Four serologic assays for leptospirosis had sensitivities of 72 to 88% and specificities of 88 to 100% in the
setting of highly endemic urban transmission, indicating that assays using enzyme-linked immunosorbency
and rapid formats may be used as alternatives to the microscopic agglutination test for diagnosing urban
leptospirosis. Testing a second sample will be required in cases with an initial negative result, since sensitivity
was low (46 to 68%) during the first week of illness.
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