Author | Da-Cruz, A. M. | |
Author | Bittar, R. | |
Author | Mattos, M. | |
Author | Oliveira Neto, M. P. | |
Author | Nogueira, R. | |
Author | Ribeiro, V. P. | |
Author | Coutinho, R. B. A. | |
Author | Coutinho, S. G. | |
Access date | 2019-05-13T12:10:57Z | |
Available date | 2019-05-13T12:10:57Z | |
Document date | 2002 | |
Citation | DA-CRUZ, Alda Maria et al. T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy. Clinical and Diagnostic Laboratory Immunology, v. 9, n. 2, p. 251-256, Mar. 2002. | pt_BR |
ISSN | 1071-412X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33039 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/cdli.9.2.251-256.2002 | |
Abstract | T-cell immune responses in patients with cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML)
were studied during the active disease, at the end of therapy, and 1 to 17 years posttherapy (long-term
follow-up). Lymphocyte proliferative responses, phenotypic characterization of CD4 and CD8 Leishmania reactive T cells, and cytokine production were assayed. Patients with active ML and CL showed higher proportions of CD4 than CD8 T cells. In CL, the healing process was associated with a decrease of CD4 and an increase of CD8 , leading to similar CD4 and CD8 proportions. This pattern was only seen in ML
after long-term therapy. Long-term follow-up of patients with CL showed a positive CD4 /CD8 ratio as
observed during the active disease, although the percentages of these T cell subsets were significantly lower.
Patients with CL did not show significant differences between gamma interferon (IFN-) and interleukin-5
(IL-5) production during the period of study. Patients with active ML presented higher IFN- and IL-5 levels
compared to patients with active CL. IL-4 was only detected during active disease. Patients long term after cure
from ML showed increasing production of IFN-, significant decrease of IL-5, and no IL-4 production. Two
apparently beneficial immunological parameters were detected in tegumentary leishmaniasis: (i) decreasing
proportions of CD4 Leishmania-reactive T cells in the absence of IL-4 production associated with cure of CL
and ML and (ii) decreasing levels of IL-5 long after cure, better detected in patients with ML. The observed
T-cell responses maintained for a long period in healed patients could be relevant for immunoprotection against reinfection and used as a parameter for determining the prognosis of patients and selecting future vaccine preparations. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | T-Cell | pt_BR |
Subject | Immune responses | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | Mucosal leishmaniasis | pt_BR |
e-ISSN | 1098-6588 | |
Embargo date | 2019-11-13 | |