Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/34926
Type
ArticleCopyright
Open access
Embargo date
2020-01-01
Collections
Metadata
Show full item record
ORAL MICROBIAL DYSBIOSIS LINKED TO WORSENED PERIODONTAL CONDITION IN RHEUMATOID ARTHRITIS PATIENTS
Author
Corrêa, Jôice Dias
Fernandes, Gabriel da Rocha
Calderaro, Débora Cerqueira
Mendonça, Santuza Maria Souza
Silva, Janine Mayra
Albiero, Mayra Laino
Cunha, Fernando Q.
Xiao, E.
Ferreira, Gilda Aparecida
Teixeira, Antônio Lúcio
Mukherjee, Chiranjit
Leys, Eugene J.
Silva, Tarcília Aparecida
Graves, Dana T.
Fernandes, Gabriel da Rocha
Calderaro, Débora Cerqueira
Mendonça, Santuza Maria Souza
Silva, Janine Mayra
Albiero, Mayra Laino
Cunha, Fernando Q.
Xiao, E.
Ferreira, Gilda Aparecida
Teixeira, Antônio Lúcio
Mukherjee, Chiranjit
Leys, Eugene J.
Silva, Tarcília Aparecida
Graves, Dana T.
Affilliation
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Universidade de Campinas. Faculdade de Odontologia. Piracicaba, SP Brazil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP Brazil
Penn Dental School. University of Pennsylvania. Philadelphia, PA USA
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
The Ohio State University. College of Dentistry. Columbus, OH USA
The Ohio State University. College of Dentistry. Columbus, OH USA
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Penn Dental School. University of Pennsylvania. Philadelphia, PA USA
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Universidade de Campinas. Faculdade de Odontologia. Piracicaba, SP Brazil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP Brazil
Penn Dental School. University of Pennsylvania. Philadelphia, PA USA
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
Universidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG Brazil
The Ohio State University. College of Dentistry. Columbus, OH USA
The Ohio State University. College of Dentistry. Columbus, OH USA
Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG Brazil
Penn Dental School. University of Pennsylvania. Philadelphia, PA USA
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL-17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.
Share