Author | Oliveira, João Vitor | |
Author | Carvalho, Tereza Cristina Xavier | |
Author | Giovanetti, Marta | |
Author | Jesus, Jaqueline Goes de | |
Author | Santos, Cleiton Silva | |
Author | Pessoa, Lorena de Brito | |
Author | Magalhães Filho, Cláudio F. Q. | |
Author | Lima, Jéssica Graziele Souza | |
Author | Carvalho, Daniel A. X. | |
Author | Figueiredo, Eduardo Manoel | |
Author | Biron, Ana Carolina | |
Author | Santos, Daiana Carlos dos | |
Author | Viana, Paloma | |
Author | Duarte, Alan Oliveira | |
Author | Pessoa, Rosana | |
Author | Souza, Gloryane Bessa | |
Author | Calcagno, Juan I | |
Author | Lima, Fernanda Washington de Mendonça | |
Author | Alcantara, Luiz Carlos Junior | |
Author | Siqueira, Isadora Cerqueira de | |
Access date | 2020-02-11T13:21:01Z | |
Available date | 2020-02-11T13:21:01Z | |
Document date | 2020 | |
Citation | OLIVEIRA, João Vitor et al. Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns. Food and Chemical Toxicology, v. 148, Suppl. 2, p. 9-14, 2020. | pt_BR |
ISSN | 2408-9761 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39841 | |
Sponsorship | HRP Alliance, part of the UNDP/
UNFPA/UNICEF/WHO/World Bank Special Programme of Research,
Development and Research Training in Human Reproduction (HRP)
and the UNICEF/UNDP/World Bank/WHO Special Programme for
Research and Training in Tropical Diseases (TDR), both cosponsored
programs hosted by the World Health Organization (WHO). The Pan
American Health Organization (PAHO) provided technical support
throughout project implementation. Financial support was also provided
by the National Council for Scientific and Technological Development
(CNPq) (425380/2016, 440685/2016-8, and 443875/2018) and by
Coordination for the Improvement of Higher Education Personnel
(CAPES) (88887.130716/2016-00 and 88881.130825/2016-00). The
authors are grateful to the physicians and nurses charged with the patients’
clinical care and would also like to thank the Arboviral Diseases Branch
Diagnostic and Reference Team (Vector-Borne
Diseases Division of the
Centers for Disease Control and Prevention) for kindly providing the reagents
necessary for MAC-ELISA
serological testing. Andris K. Walter provided
English language revision and manuscript copyediting assistance. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Infecção congênita | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Vigilância neonatal | pt_BR |
Subject in Portuguese | Vírus zika | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/ijgo.13042 | |
Abstract | To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak. Methods: A prospective study enrolled microcephalic and normocephalic newborns
with suspected CZI between January and December 2016. Serology (immunoglobulins
IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction
(RT-qPCR)
for the Zika virus were performed. Demographic and clinical characteristics
of newborns with and without microcephaly were compared.
Results: Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic.
The majority of these cases were born between January and May 2016. IgM and
IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic
newborn blood samples, respectively. Six (24%) microcephalic newborns tested
positive for Zika virus by RT-qPCR
in urine or placenta samples. Thirteen (11.8%)
normocephalic newborns also tested positive for Zika virus by PCR in urine,
plasma, or placenta samples, while IgM antibodies against Zika were detected in 4
(4.2%) others.
Conclusions: Identification of 17 normocephalic CZI cases, confirmed by IgM serology
or RT-qPCR
for Zika virus, provides evidence that CZI can present asymptomatically at
birth. This finding highlights the need for prenatal and neonatal screening for Zika virus
in endemic regions. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | Congenital infection | pt_BR |
Subject | Microcephaly | pt_BR |
Subject | Neonatal surveillance | pt_BR |
Subject | Zika virus | pt_BR |
Subject | Brazil | pt_BR |