Author | Biembengut, Ísis Venturi | pt_BR |
Author | Souza, Tatiana de Arruda Campos Brasil de | pt_BR |
Access date | 2020-04-23T19:13:03Z | |
Available date | 2020-04-23T19:13:03Z | |
Document date | 2020 | |
Citation | BIEMBENGUT, Ísis Venturi; SOUZA, Tatiana de Arruda Campos Brasil de. Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID19 treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, p. 1-10, 17 Apr. 2020. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40946 | |
Language | eng | pt_BR |
Publisher | Fiocruz/IOC | pt_BR |
Later version | https://www.arca.fiocruz.br/handle/icict/42002 | |
Rights | open access | pt_BR |
Subject in Portuguese | Coronavírus | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Title | Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment | en |
Type | Preprint | pt_BR |
DOI | 10.1590/0074-02760200179 | pt_BR |
Abstract | SARS-CoV-2 infection depends on viral polyprotein processing, an event catalyzed by the main proteinase Mpro. The solution of the SARS-CoV-2 Mpro tridimensional structure in the last month allowed the investigation of potential inhibitors of viral replication. As objective, this work aims to provide first evidences of the applicability of commercial y approved drugs to treat COVID-19. As methods used in this research: We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Thereby we have as findings that, The higher scores interactions include antiviral components and drugs classified as coagulation modifiers, ACE and dipeptidyl peptidase 4 inhibitors, antimigraine agents, antihistamine. And finally as main conclusions: Our result evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV main protease Mpro and human coagulation factors thrombin and Factor Xa. | en |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
Subject | Structure | en |
Subject | Ligand binding | en |
Subject | In silico approach | en |
Subject | COVID-19 | en |
Subject | SARS-CoV-2 Mpro | en |
Subject | Coronavírus | en |
DeCS | SARS-CoV-2 | pt_BR |
DeCS | COVID-19 | pt_BR |
DeCS | Infecções por Coronavirus | pt_BR |
DeCS | Proteínas de Transporte | pt_BR |
DeCS | Simulação por Computador | pt_BR |
DeCS | Estrutura Molecular | pt_BR |
e-ISSN | 1678-8060 | pt_BR |