Author | Savino, Wilson | |
Author | Cruz, Daniella Mendes da | |
Author | Silva, João S. | |
Author | Dardenne, Mireille | |
Author | Almeida, Vinicius Cotta de | |
Access date | 2020-05-06T17:18:39Z | |
Available date | 2020-05-06T17:18:39Z | |
Document date | 2002 | |
Citation | SAVINO, Wilson et al. Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines?. TRENDS in Immunology, v. 23, n. 6, p. 305-312, June 2002. | pt_BR |
ISSN | 1471-4906 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/41137 | |
Language | eng | pt_BR |
Publisher | Elsevier 12 Months | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Migração intratímica de células T | pt_BR |
Subject in Portuguese | Interação combinatória | pt_BR |
Subject in Portuguese | Matriz extracelular | pt_BR |
Subject in Portuguese | Quimiocinas | pt_BR |
Title | Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/S1471-4906(02)02224-X | |
Abstract | Cell migration is crucial for intrathymic T-cell differentiation. Chemokines
and extracellular matrix proteins per se induce thymocyte migration, and
recent data suggest a combinatorial role for these molecules in this event.
For example, thymocyte migration induced by fibronectin plus
CXCL12/SDF1-α (stromal cell-derived factor1-α) is higher than that elicited
by the chemokine alone. If such interactions are relevant in the thymus,
abnormal expression of any of these ligands and/or their corresponding
receptors will lead to defects in thymocyte migration. At least in the murine
model of Chagas disease, this seems to be the case. Therefore a better
knowledge of this complex biological circuitry will provide new clues for
understanding thymus physiology and designing therapeutic strategies
targeting developing T cells. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Imunologia. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Université Paris V, Paris. Hôpital Necker, CNRS UMR 8603. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Intrathymic T-cell migration | pt_BR |
Subject | Combinatorial interplay | pt_BR |
Subject | Chemokines | pt_BR |
Subject | Extracellular matrix | pt_BR |
e-ISSN | 1471-4981 | |
Embargo date | 2022-01-01 | |