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https://www.arca.fiocruz.br/handle/icict/42361
CHARACTERIZATION OF β-CYCLODEXTRIN/MYRTENOL COMPLEX AND ITS PROTECTIVE EFFECT AGAINST NOCICEPTIVE BEHAVIOR AND COGNITIVE IMPAIRMENT IN A CHRONIC MUSCULOSKELETAL PAIN MODEL
Author
Heimfarth, Luana
Anjos, Klécia Santos dos
Carvalho, Yasmim Maria Barbosa Gomes de
Santos, Bruno Lucena dos
Serafini, Mairim Russo
Carvalho Neto, Antônio Guilherme de
Nunes, Paula Santos
Beserra Filho, José Ivo Araújo
Silva, Sara Pereira da
Ribeiro, Alessandra Mussi
Bezerra, Daniel Pereira
Marreto, Ricardo Neves
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Coutinho, Henrique Douglas Melo
Scotti, Marcus T.
Scotti, Luciana
Quintans Júnior, Lucindo José
Anjos, Klécia Santos dos
Carvalho, Yasmim Maria Barbosa Gomes de
Santos, Bruno Lucena dos
Serafini, Mairim Russo
Carvalho Neto, Antônio Guilherme de
Nunes, Paula Santos
Beserra Filho, José Ivo Araújo
Silva, Sara Pereira da
Ribeiro, Alessandra Mussi
Bezerra, Daniel Pereira
Marreto, Ricardo Neves
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Coutinho, Henrique Douglas Melo
Scotti, Marcus T.
Scotti, Luciana
Quintans Júnior, Lucindo José
Affilliation
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia de Tecidos e Imunofarmacologia. Salvador, BA, Brasil .
Federal University of Goias. School of Pharmacy. Goiania, GO, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil.
. Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia de Tecidos e Imunofarmacologia. Salvador, BA, Brasil .
Federal University of Goias. School of Pharmacy. Goiania, GO, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil.
. Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil.
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.
Abstract
Myrtenol has gained wide interest because of its pharmacological profiles, mainly for treatment of chronic diseases. To improve the solubility of myrtenol, the formation of inclusion complexes with β-cyclodextrin was performed by physical mixture, kneading process or slurry complexation (SC) methods and characterized using thermal analysis, XRD, SEM and NMR. From these results, myrtenol complexed by SC was successfully complexed into β-cyclodextrin cavity. The interaction between myrtenol and β-cyclodextrin was confirmed by molecular docking. Hence, the SC β-cyclodextrin-myrtenol complex was evaluate for its anti-hyperalgesic, anxiolytic and antioxidant activity in a fibromyalgia model. Results show that myrtenol and β-cyclodextrin form a stable complex and have anti-hyperalgesic effect, improve the cognitive impairment caused and have an anxiolytic-like effect. Furthermore, the β-cyclodextrin/myrtenol complex decrease lipoperoxidation, increased catalase activity and a reduce SOD/CAT ratio. Therefore, β-cyclodextrin/myrtenol complex reduce painful behavior, improves motor skills and emotional behavior and decreases oxidative stress in a fibromyalgia model.
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