Author | Santos, Hayna Malta | |
Author | Costa, Jaqueline França | |
Author | Macedo, Amanda | |
Author | Queiroz, Artur Trancoso Lopo de | |
Author | Fukutani, Kiyoshi Ferreira | |
Author | Muxel, Sandra Marcia | |
Author | Cunha, Antonio Ricardo Khouri | |
Author | Van Weyenbergh, Johan | |
Author | Boaventura, Viviane | |
Author | Barral, Aldina Maria Prado | |
Author | Costa, Jackson M | |
Author | Floh, Eny Iochevet Segal | |
Author | Andrade, Bruno de Bezerril | |
Author | Winter, Lucile M Floeter | |
Author | Borges, Valéria Matos | |
Access date | 2020-08-05T11:57:29Z | |
Available date | 2020-08-05T11:57:29Z | |
Document date | 2020 | |
Citation | SANTOS, Hayna Malta et al. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis. Scientific Reports, v. 10, 2020. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42541 | |
Sponsorship | Fundação
de Amparo à Pesquisa do Estado da Bahia (FAPESB) and Research Program of Gonçalo Moniz Institut of
Fiocruz-BA. (VMB). | pt_BR |
Language | eng | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Leishmaniose tegumentar | pt_BR |
Subject in Portuguese | Poliamina | pt_BR |
Subject in Portuguese | Aminoacidos | pt_BR |
Title | Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-020-67432-5 | |
Abstract | Tegumentary leishmaniasis (TL) is a parasitic disease that can result in wide spectrum clinical manifestations. It is necessary to understand host and parasite determinants of clinical outcomes to identify novel therapeutic targets. Previous studies have indicated that the polyamine biosynthetic pathway is critical for Leishmania growth and survival. Despite its importance, expression of the such pathway has not been previously investigated in TL patients. We performed an exploratory analysis employing Systems Biology tools to compare circulating polyamines and amino acid concentration as well as polyamine pathway gene expression in cutaneous lesions patients presenting with distinct TL disease presentations. Diffuse cutaneous leishmaniasis (DCL) was associated with higher concentrations of amino acids, polyamines and its substrate transporters than mucosal cutaneous leishmaniasis or localized cutaneous leishmaniasis. In addition, the RNA expression of polyamine-related genes of patients lesions from two separate cohorts demonstrated that differential activation of this pathway is associated with parasite loads and able to discriminate the clinical spectrum of TL. Taken together, our findings highlight a new aspect of DCL immunopathogenesis indicating that the polyamine pathway may be explored as a novel therapeutic target to control disease burden. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédica. Departamento de Botânica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / University of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Leuven, Belgium. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Maranhão. São Luis, MA, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Botânica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | Leishmaniasis Cutaneous | pt_BR |
Subject | Leishmaniasis diffuse | pt_BR |
Subject | Polyamines | pt_BR |
Subject | Amino Acids | pt_BR |