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https://www.arca.fiocruz.br/handle/icict/45752
BEYOND INFLAMMATION: CENTRALLY MEDIATED ANTINOCICEPTIVE PROPERTIES OF SPIRULINA PLATENSIS LEB-18 BIOMASS VIA THE OPIOID SYSTEM
Author
Affilliation
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Rio Grande. College of Chemistry and Food Engineering. Rio Grande, RS, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Rio Grande. College of Chemistry and Food Engineering. Rio Grande, RS, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.
Abstract
The management of pain is a world health issue. Available painkillers induce undesired side effects and are
sometimes inefficient. Spirulina biomass has promoted anti-inflammatory activity in preclinical and clinical
trials. This work characterizes the antinociceptive properties of Spirulina platensis LEB-18 biomass (SP-LEB18)
and their mechanisms of action. In the CFA model in mice, SP-LEB18 reduced paw edema and mechanical
allodynia, confirming its anti-inflammatory action and showing its antinociceptive activity. Cytokines levels
were evaluated by ELISA; SP-LEB18 promoted an increase of IL-10 levels and a reduction of TNF-α and IL-1β
levels. SP-LEB18 promoted centrally mediated antinociception, as indicated by the tail flick test. When the same
set of experiments was conducted with IL-10 knockout mice, the antinociception was still detected in the tail
flick test, but not in the CFA model. Pretreatment with naloxone abolished the effect of SP-LEB18, demonstrating
a pure antinociceptive action of Spirulina biomass via the opioid system.
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