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https://www.arca.fiocruz.br/handle/icict/45980
MODERATE AND SEVERE PERIODONTITIS ARE POSITIVELY ASSOCIATED WITH METABOLIC SYNDROME
Author
Gomes Filho, Isaac Suzart
Balinha, Izadora da S. C. E.
Cruz, Simone S. da
Trindade, Soraya C.
Cerqueira, Eneida de M. M.
Soares, Johelle de S. Passos
Coelho, Julita Maria F.
Ladeia, Ana Marice Teixeira
Vianna, Maria Isabel P.
Hintz, Alexandre M.
Santana, Teresinha C. de
Santos, Pedro P. dos
Figueiredo, Ana Claúdia M. G.
Silva, Ivana C. O. da
Scannapieco, Frank A.
Barreto, Maurício Lima
Loomer, Peter M.
Balinha, Izadora da S. C. E.
Cruz, Simone S. da
Trindade, Soraya C.
Cerqueira, Eneida de M. M.
Soares, Johelle de S. Passos
Coelho, Julita Maria F.
Ladeia, Ana Marice Teixeira
Vianna, Maria Isabel P.
Hintz, Alexandre M.
Santana, Teresinha C. de
Santos, Pedro P. dos
Figueiredo, Ana Claúdia M. G.
Silva, Ivana C. O. da
Scannapieco, Frank A.
Barreto, Maurício Lima
Loomer, Peter M.
Affilliation
Múltipla - Ver em Notas.
Abstract
Objective This study investigated the association between periodontitis severity (exposure) and metabolic syndrome (MetS -
outcome), using two criteria for diagnosis of the outcome, since this relationship remains unexplored.
Materials and methods A case-control study was conducted with 870 individuals: 408 with firstMetS diagnosis (cases) and 462
without MetS (controls). Participants’ general information was obtained using a questionnaire and laboratory data was collected
from medical records. Periodontitis severity criteria followed the Center for Disease Control and Prevention: none, mild,
moderate, and severe. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by logistic regression analysis.
Results Findings showed a positive association between moderate and severe periodontitis and MetS: ORadjusted = 1.64 (95%CI:
1.01 to 2.68) and ORadjusted = 1.94 (95% CI: 1.19 to 3.16), respectively, after adjustment for age, sex, schooling level, smoking
habit, and cardiovascular disease. The adjusted measurements showed that among individuals with moderate or severe periodontitis,
the probability of having MetS was around two times greater than among those without periodontitis, and that the
chance was greater among participants with severe periodontitis than those with moderate periodontitis.
Conclusion An association between the severity of periodontal status and MetS was found, suggesting a possible relationship
between the two diseases.
Clinical relevance MetS influences the etiology of cardiovascular diseases, one of the leading causes of mortality worldwide. The
findings suggest that the greater the severity of periodontitis, the greater is the association magnitude with MetS. The health
professional needs to recognize that the importance of periodontal disease may play in MetS.
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