Author | Gomes, Yago Côrtes Pinheiro | |
Author | Silva, Marcus Tulius Teixeira | |
Author | Leite, Ana Claudia Celestino Bezerra | |
Author | Lima, Marco Antonio Sales Dantas | |
Author | Araújo, Abelardo Queiroz Campos | |
Author | Silva Filho, Isaac Lima | |
Author | Vicente, Ana Carolina Paulo | |
Author | Espíndola, Otávio de Melo | |
Access date | 2021-12-13T16:41:55Z | |
Available date | 2021-12-13T16:41:55Z | |
Document date | 2021 | |
Citation | GOMES, Yago Côrtes Pinheiro et al. Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression. The Journal of general virology, v. 102, n. 9, p. 1-11, 2021 | pt_BR |
ISSN | 0022-1317 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50339 | |
Language | eng | pt_BR |
Publisher | Microbiology Society | pt_BR |
Rights | restricted access | pt_BR |
Title | Polymorphisms in HTLV-1 Tax-responsive elements in HTLV- 1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression | pt_BR |
Type | Article | pt_BR |
DOI | 10.1099/jgv.0.001649 | |
Abstract | Human T-lymphotropic virus type 1 (HTLV-1) provirus expression is mainly directed by Tax-responsive elements (TRE) within the long terminal repeats (LTR). Mutations in TRE can reduce provirus expression and since a high proviral load (PVL) is a risk factor for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we evaluated polymorphisms in the 5' LTR and the association with PVL and disease progression. HTLV-1 LTR and tax sequences derived from asymptomatic carriers (AC) and HAM/TSP patients followed in a longitudinal study were analysed according to PVL and clinical severity. Individuals infected with HTLV-1 presenting the canonical TRE, considering strain ATK-1 as the consensus, displayed sustained higher PVL. By contrast, an LTR A125G mutation in TRE was associated with slightly reduced PVL only in HAM/TSP patients, although it did not influence the speed of disease progression. Moreover, this polymorphism was frequent in Latin American strains of the HTLV-1 Cosmopolitan Transcontinental subtype. Therefore, polymorphisms in the 5' TRE of HTLV-1 may represent one of the factors influencing PVL in HAM/TSP patients, especially in the Latin American population. Indeed, higher PVL in the peripheral blood has been associated with an increased inflammatory activity in the spinal cord and to a poorer prognosis in HAM/TSP. However, this event was not associated with TRE polymorphisms. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HAM/TSP | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Genetic polymorphism | pt_BR |
Subject | Proviral load | pt_BR |
Subject | Tax-responsive elements | pt_BR |